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Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood

Oxidative stress (OS) is a common pathogenic factor involved in the onset of several diseases in humans, from immunologic disorders to malignancy, being a serious public health problem. In perinatal period, OS has been associated with adverse outcome of pregnancy and neonatal diseases. Dangerous eff...

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Autores principales: Longini, Mariangela, Belvisi, Elisa, Proietti, Fabrizio, Bazzini, Francesco, Buonocore, Giuseppe, Perrone, Serafina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420435/
https://www.ncbi.nlm.nih.gov/pubmed/28512386
http://dx.doi.org/10.1155/2017/1758432
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author Longini, Mariangela
Belvisi, Elisa
Proietti, Fabrizio
Bazzini, Francesco
Buonocore, Giuseppe
Perrone, Serafina
author_facet Longini, Mariangela
Belvisi, Elisa
Proietti, Fabrizio
Bazzini, Francesco
Buonocore, Giuseppe
Perrone, Serafina
author_sort Longini, Mariangela
collection PubMed
description Oxidative stress (OS) is a common pathogenic factor involved in the onset of several diseases in humans, from immunologic disorders to malignancy, being a serious public health problem. In perinatal period, OS has been associated with adverse outcome of pregnancy and neonatal diseases. Dangerous effects of OS are mediated by increased production of free radicals (FRs) following various mechanisms, such as hypoxia, ischemia reperfusion, hyperoxia, inflammation, mitochondrial dysfunction, Fenton chemistry, and prostaglandin metabolism. FRs have short half-life, and their measurement in vivo is faced with many challenges. However, oxyradical derivatives are stable and thus may be measured and monitored repeatedly. The quantification of OS is based on the measurement of specific biomarkers in biologic fluids and tissues, which reflect induced oxidative damage to lipids, proteins, and DNA. Prostanoids, non–protein-bound iron (NPBI), and advanced oxidation protein products (AOPP) are actually considered truly specific and reliable for neonatal injury. Defining reference values for these biomarkers is necessary to investigate their role in neonatal diseases or also to evaluate the success of treatments. In this work, we wanted to define laboratory reference values for biomarkers of OS in a healthy population of term newborns.
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spelling pubmed-54204352017-05-16 Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood Longini, Mariangela Belvisi, Elisa Proietti, Fabrizio Bazzini, Francesco Buonocore, Giuseppe Perrone, Serafina Mediators Inflamm Research Article Oxidative stress (OS) is a common pathogenic factor involved in the onset of several diseases in humans, from immunologic disorders to malignancy, being a serious public health problem. In perinatal period, OS has been associated with adverse outcome of pregnancy and neonatal diseases. Dangerous effects of OS are mediated by increased production of free radicals (FRs) following various mechanisms, such as hypoxia, ischemia reperfusion, hyperoxia, inflammation, mitochondrial dysfunction, Fenton chemistry, and prostaglandin metabolism. FRs have short half-life, and their measurement in vivo is faced with many challenges. However, oxyradical derivatives are stable and thus may be measured and monitored repeatedly. The quantification of OS is based on the measurement of specific biomarkers in biologic fluids and tissues, which reflect induced oxidative damage to lipids, proteins, and DNA. Prostanoids, non–protein-bound iron (NPBI), and advanced oxidation protein products (AOPP) are actually considered truly specific and reliable for neonatal injury. Defining reference values for these biomarkers is necessary to investigate their role in neonatal diseases or also to evaluate the success of treatments. In this work, we wanted to define laboratory reference values for biomarkers of OS in a healthy population of term newborns. Hindawi 2017 2017-04-23 /pmc/articles/PMC5420435/ /pubmed/28512386 http://dx.doi.org/10.1155/2017/1758432 Text en Copyright © 2017 Mariangela Longini et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Longini, Mariangela
Belvisi, Elisa
Proietti, Fabrizio
Bazzini, Francesco
Buonocore, Giuseppe
Perrone, Serafina
Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title_full Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title_fullStr Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title_full_unstemmed Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title_short Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood
title_sort oxidative stress biomarkers: establishment of reference values for isoprostanes, aopp, and npbi in cord blood
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420435/
https://www.ncbi.nlm.nih.gov/pubmed/28512386
http://dx.doi.org/10.1155/2017/1758432
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