Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy

Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, expl...

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Detalles Bibliográficos
Autores principales: Cui, Wenpeng, Min, Xu, Xu, Xiaohong, Du, Bing, Luo, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420438/
https://www.ncbi.nlm.nih.gov/pubmed/28512642
http://dx.doi.org/10.1155/2017/3797802
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author Cui, Wenpeng
Min, Xu
Xu, Xiaohong
Du, Bing
Luo, Ping
author_facet Cui, Wenpeng
Min, Xu
Xu, Xiaohong
Du, Bing
Luo, Ping
author_sort Cui, Wenpeng
collection PubMed
description Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.
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spelling pubmed-54204382017-05-16 Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy Cui, Wenpeng Min, Xu Xu, Xiaohong Du, Bing Luo, Ping J Diabetes Res Review Article Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies. Hindawi 2017 2017-04-23 /pmc/articles/PMC5420438/ /pubmed/28512642 http://dx.doi.org/10.1155/2017/3797802 Text en Copyright © 2017 Wenpeng Cui et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cui, Wenpeng
Min, Xu
Xu, Xiaohong
Du, Bing
Luo, Ping
Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title_full Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title_fullStr Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title_full_unstemmed Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title_short Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
title_sort role of nuclear factor erythroid 2-related factor 2 in diabetic nephropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420438/
https://www.ncbi.nlm.nih.gov/pubmed/28512642
http://dx.doi.org/10.1155/2017/3797802
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