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Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production. Compared to early anti-DNA and anti-chromatin responses, other autoantibod...

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Detalles Bibliográficos
Autores principales:	Shi, Guilan, Abbott, Kennady N., Wu, Wenbo, Salter, Russell D., Keyel, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420570/ https://www.ncbi.nlm.nih.gov/pubmed/28533778 http://dx.doi.org/10.3389/fimmu.2017.00522

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