Cargando…

Association between telomere length and complete blood count in US adults

INTRODUCTION: Telomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults. MATERIAL AND METHODS: Participant...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazidi, Mohsen, Penson, Peter, Banach, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420635/
https://www.ncbi.nlm.nih.gov/pubmed/28507575
http://dx.doi.org/10.5114/aoms.2017.67281
_version_ 1783234430169513984
author Mazidi, Mohsen
Penson, Peter
Banach, Maciej
author_facet Mazidi, Mohsen
Penson, Peter
Banach, Maciej
author_sort Mazidi, Mohsen
collection PubMed
description INTRODUCTION: Telomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults. MATERIAL AND METHODS: Participants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2002 who had essential data on total CBC and TL were studied. We computed age- and race-adjusted mean values for total CBC using analysis of covariance (ANCOVA). All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). RESULTS: Of the 8892 eligible participants, 47.8% (n = 4123) were men. The mean age was 41.8 years overall, 41.0 years in men and 42.6 in women (p = 0.238). The sex-stratified ANCOVA showed no significant difference in the total CBC across TL quartiles (all p > 0.05) in both sexes. In the adjusted model, there was a significant negative relationship with monocyte count (β = –0.051, 95% CI: –0.422; –0.142), mean cell hemoglobin (β = –0.051, 95% CI: –0.038; –0.011) and red cell distribution width (β = –0.031, 95% CI: –0.054; –0.003), while there was a significant positive relationship with basophil ratio (β = 0.046, 95% CI: 0.049–0.171). CONCLUSIONS: These results support the possibility that telomere attrition may be a marker for reduced proliferative reserve in hematopoietic progenitor cells.
format Online
Article
Text
id pubmed-5420635
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-54206352017-05-15 Association between telomere length and complete blood count in US adults Mazidi, Mohsen Penson, Peter Banach, Maciej Arch Med Sci Clinical Research INTRODUCTION: Telomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults. MATERIAL AND METHODS: Participants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2002 who had essential data on total CBC and TL were studied. We computed age- and race-adjusted mean values for total CBC using analysis of covariance (ANCOVA). All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY). RESULTS: Of the 8892 eligible participants, 47.8% (n = 4123) were men. The mean age was 41.8 years overall, 41.0 years in men and 42.6 in women (p = 0.238). The sex-stratified ANCOVA showed no significant difference in the total CBC across TL quartiles (all p > 0.05) in both sexes. In the adjusted model, there was a significant negative relationship with monocyte count (β = –0.051, 95% CI: –0.422; –0.142), mean cell hemoglobin (β = –0.051, 95% CI: –0.038; –0.011) and red cell distribution width (β = –0.031, 95% CI: –0.054; –0.003), while there was a significant positive relationship with basophil ratio (β = 0.046, 95% CI: 0.049–0.171). CONCLUSIONS: These results support the possibility that telomere attrition may be a marker for reduced proliferative reserve in hematopoietic progenitor cells. Termedia Publishing House 2017-04-20 2017-04-01 /pmc/articles/PMC5420635/ /pubmed/28507575 http://dx.doi.org/10.5114/aoms.2017.67281 Text en Copyright: © 2017 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Mazidi, Mohsen
Penson, Peter
Banach, Maciej
Association between telomere length and complete blood count in US adults
title Association between telomere length and complete blood count in US adults
title_full Association between telomere length and complete blood count in US adults
title_fullStr Association between telomere length and complete blood count in US adults
title_full_unstemmed Association between telomere length and complete blood count in US adults
title_short Association between telomere length and complete blood count in US adults
title_sort association between telomere length and complete blood count in us adults
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420635/
https://www.ncbi.nlm.nih.gov/pubmed/28507575
http://dx.doi.org/10.5114/aoms.2017.67281
work_keys_str_mv AT mazidimohsen associationbetweentelomerelengthandcompletebloodcountinusadults
AT pensonpeter associationbetweentelomerelengthandcompletebloodcountinusadults
AT banachmaciej associationbetweentelomerelengthandcompletebloodcountinusadults