Cargando…

Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients

AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN. PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline a...

Descripción completa

Detalles Bibliográficos
Autores principales: Dayem, Soha Abd El, Bohy, Abo El Magd El, Hamed, Mona, Ahmed, Solaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ID Design 2012/DOOEL Skopje 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420772/
https://www.ncbi.nlm.nih.gov/pubmed/28507626
http://dx.doi.org/10.3889/oamjms.2017.034
_version_ 1783234461624696832
author Dayem, Soha Abd El
Bohy, Abo El Magd El
Hamed, Mona
Ahmed, Solaf
author_facet Dayem, Soha Abd El
Bohy, Abo El Magd El
Hamed, Mona
Ahmed, Solaf
author_sort Dayem, Soha Abd El
collection PubMed
description AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN. PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Forty diabetic patients did renal Doppler at baseline & after three years. RESULTS: HbA1, waist/hip ratio, albumin/creatinine ratio, lipid profile, NGAL, KIM-1, L-FABP and resistivity index (RI) were significantly increased in follow-up. Twenty patients (41.7%) showed progression to albuminuria. RI showed a significant increase in follow-up study. ROC curve showed that RI and NGAL had the highest sensitivity (100%), followed by L-FABP (90%) and lastly KIM-1 (63.6%) in the prediction of DN. CONCLUSION: High RI, NGAL, KIM-1 & L-FABP can be considered as early markers of diabetic nephropathy in type 1 diabetics and are associated with its progression over time, independent of albuminuria.
format Online
Article
Text
id pubmed-5420772
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher ID Design 2012/DOOEL Skopje
record_format MEDLINE/PubMed
spelling pubmed-54207722017-05-15 Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients Dayem, Soha Abd El Bohy, Abo El Magd El Hamed, Mona Ahmed, Solaf Open Access Maced J Med Sci Clinical Science AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN. PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Forty diabetic patients did renal Doppler at baseline & after three years. RESULTS: HbA1, waist/hip ratio, albumin/creatinine ratio, lipid profile, NGAL, KIM-1, L-FABP and resistivity index (RI) were significantly increased in follow-up. Twenty patients (41.7%) showed progression to albuminuria. RI showed a significant increase in follow-up study. ROC curve showed that RI and NGAL had the highest sensitivity (100%), followed by L-FABP (90%) and lastly KIM-1 (63.6%) in the prediction of DN. CONCLUSION: High RI, NGAL, KIM-1 & L-FABP can be considered as early markers of diabetic nephropathy in type 1 diabetics and are associated with its progression over time, independent of albuminuria. ID Design 2012/DOOEL Skopje 2017-03-20 /pmc/articles/PMC5420772/ /pubmed/28507626 http://dx.doi.org/10.3889/oamjms.2017.034 Text en Copyright: © 2017 Soha M. Abd El Dayem, Abo El Magd El Bohy, Mona Hamed, Solaf Ahmed. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Dayem, Soha Abd El
Bohy, Abo El Magd El
Hamed, Mona
Ahmed, Solaf
Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title_full Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title_fullStr Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title_full_unstemmed Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title_short Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients
title_sort follow up of value of the intrarenal resistivity indices and different renal biomarkers for early identification of diabetic nephropathy in type 1 diabetic patients
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420772/
https://www.ncbi.nlm.nih.gov/pubmed/28507626
http://dx.doi.org/10.3889/oamjms.2017.034
work_keys_str_mv AT dayemsohaabdel followupofvalueoftheintrarenalresistivityindicesanddifferentrenalbiomarkersforearlyidentificationofdiabeticnephropathyintype1diabeticpatients
AT bohyaboelmagdel followupofvalueoftheintrarenalresistivityindicesanddifferentrenalbiomarkersforearlyidentificationofdiabeticnephropathyintype1diabeticpatients
AT hamedmona followupofvalueoftheintrarenalresistivityindicesanddifferentrenalbiomarkersforearlyidentificationofdiabeticnephropathyintype1diabeticpatients
AT ahmedsolaf followupofvalueoftheintrarenalresistivityindicesanddifferentrenalbiomarkersforearlyidentificationofdiabeticnephropathyintype1diabeticpatients