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Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification

Amyloid fibril formation has been implicated in the pathogenesis of neurodegenerative diseases. Fibrillation generates numerous conformers. Presumably, the conformers may possess specific biological properties, thus providing a biochemical framework for strains of prions. However, the precise relati...

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Detalles Bibliográficos
Autores principales:	Jung, Byung Chul, Lim, Yoon-Ju, Bae, Eun-Jin, Lee, Jun Sung, Choi, Min Sun, Lee, Michael K, Lee, He-Jin, Kim, Yoon Suk, Lee, Seung-Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420798/ https://www.ncbi.nlm.nih.gov/pubmed/28386127 http://dx.doi.org/10.1038/emm.2017.1

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