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Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study
OBJECTIVE: Higher levels of physical activity (PA) reduce the risk of cognitive impairment, but the underlying mechanisms are unclear. Using longitudinal data from the Cardiovascular Health Study, we examined whether PA predicted plasma Aβ levels and risk for cognitive decline 9–13 years later. METH...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420805/ https://www.ncbi.nlm.nih.gov/pubmed/28491896 http://dx.doi.org/10.1002/acn3.397 |
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author | Stillman, Chelsea M. Lopez, Oscar L. Becker, James T. Kuller, Lewis H. Mehta, Pankaj D. Tracy, Russell P. Erickson, Kirk I. |
author_facet | Stillman, Chelsea M. Lopez, Oscar L. Becker, James T. Kuller, Lewis H. Mehta, Pankaj D. Tracy, Russell P. Erickson, Kirk I. |
author_sort | Stillman, Chelsea M. |
collection | PubMed |
description | OBJECTIVE: Higher levels of physical activity (PA) reduce the risk of cognitive impairment, but the underlying mechanisms are unclear. Using longitudinal data from the Cardiovascular Health Study, we examined whether PA predicted plasma Aβ levels and risk for cognitive decline 9–13 years later. METHODS: Linear and logistic regressions (controlling for APOE status, age, gender, body mass index, cardiovascular disease, brain white matter lesions, and cystatin C levels) tested associations between PA, Aβ, and cognitive impairment in a sample of 149 cognitively normal older adults (mean age 83 years). RESULTS: More PA at baseline predicted lower levels of Aβ 9–13 years later. Higher Aβ levels at year 9 predicted greater risk for cognitive impairment at year 13. Levels of Aβ at year 9 mediated the relationship between PA and cognitive impairment. INTERPRETATION: Greater PA may reduce plasma levels of a neurotoxic peptide at an age when the risk for cognitive impairment is especially high. |
format | Online Article Text |
id | pubmed-5420805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54208052017-05-10 Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study Stillman, Chelsea M. Lopez, Oscar L. Becker, James T. Kuller, Lewis H. Mehta, Pankaj D. Tracy, Russell P. Erickson, Kirk I. Ann Clin Transl Neurol Research Articles OBJECTIVE: Higher levels of physical activity (PA) reduce the risk of cognitive impairment, but the underlying mechanisms are unclear. Using longitudinal data from the Cardiovascular Health Study, we examined whether PA predicted plasma Aβ levels and risk for cognitive decline 9–13 years later. METHODS: Linear and logistic regressions (controlling for APOE status, age, gender, body mass index, cardiovascular disease, brain white matter lesions, and cystatin C levels) tested associations between PA, Aβ, and cognitive impairment in a sample of 149 cognitively normal older adults (mean age 83 years). RESULTS: More PA at baseline predicted lower levels of Aβ 9–13 years later. Higher Aβ levels at year 9 predicted greater risk for cognitive impairment at year 13. Levels of Aβ at year 9 mediated the relationship between PA and cognitive impairment. INTERPRETATION: Greater PA may reduce plasma levels of a neurotoxic peptide at an age when the risk for cognitive impairment is especially high. John Wiley and Sons Inc. 2017-04-14 /pmc/articles/PMC5420805/ /pubmed/28491896 http://dx.doi.org/10.1002/acn3.397 Text en © 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Stillman, Chelsea M. Lopez, Oscar L. Becker, James T. Kuller, Lewis H. Mehta, Pankaj D. Tracy, Russell P. Erickson, Kirk I. Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title | Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title_full | Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title_fullStr | Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title_full_unstemmed | Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title_short | Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study |
title_sort | physical activity predicts reduced plasma β amyloid in the cardiovascular health study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420805/ https://www.ncbi.nlm.nih.gov/pubmed/28491896 http://dx.doi.org/10.1002/acn3.397 |
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