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Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target
The K-, N-, and HRas small GTPases are key regulators of cell physiology and are frequently mutated in human cancers. Despite intensive research, previous efforts to target hyperactive Ras based on known mechanisms of Ras signaling have been met with little success. Several studies have provided com...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421135/ https://www.ncbi.nlm.nih.gov/pubmed/26423697 http://dx.doi.org/10.2174/1389557515666151001152212 |