Cargando…

Cancer Immunoprevention and Public Health

The power of cancer immune surveillance has been documented beyond doubt, and the successful exploitation of immune response to cancer has started a new era in the war against cancer. Cancer biologists have recognized immunoevasion as an emerging hallmark in addition to the six hallmarks of cancer....

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Sandeep K., Dorak, Mehmet Tevfik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421153/
https://www.ncbi.nlm.nih.gov/pubmed/28534024
http://dx.doi.org/10.3389/fpubh.2017.00101
_version_ 1783234545394384896
author Singh, Sandeep K.
Dorak, Mehmet Tevfik
author_facet Singh, Sandeep K.
Dorak, Mehmet Tevfik
author_sort Singh, Sandeep K.
collection PubMed
description The power of cancer immune surveillance has been documented beyond doubt, and the successful exploitation of immune response to cancer has started a new era in the war against cancer. Cancer biologists have recognized immunoevasion as an emerging hallmark in addition to the six hallmarks of cancer. Besides the natural connection between the immune system and cancer development, most established environmental risk factors are now known to interfere with immune surveillance mechanisms. Genetic variations regulating immunity may also modulate cancer susceptibility, but evidence for this is currently limited. Molecular cross talk linking “immune” and “genomic” surveillance pathways has been characterized. It appears that immune mechanisms may contribute to the effects of common cancer risk factors. We provide an updated overview of evidence for cancer immune surveillance, cancer risk factors interfering with it, and interventions to enhance cancer immune surveillance as tools to complement ongoing vaccine development efforts for cancer immunoprevention. Although there is a lot of support for cancer immunoprevention with simple lifestyle modifications from observational studies, there is an urgent need for clinical trials to establish the effectiveness of this approach for public health benefits.
format Online
Article
Text
id pubmed-5421153
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-54211532017-05-22 Cancer Immunoprevention and Public Health Singh, Sandeep K. Dorak, Mehmet Tevfik Front Public Health Public Health The power of cancer immune surveillance has been documented beyond doubt, and the successful exploitation of immune response to cancer has started a new era in the war against cancer. Cancer biologists have recognized immunoevasion as an emerging hallmark in addition to the six hallmarks of cancer. Besides the natural connection between the immune system and cancer development, most established environmental risk factors are now known to interfere with immune surveillance mechanisms. Genetic variations regulating immunity may also modulate cancer susceptibility, but evidence for this is currently limited. Molecular cross talk linking “immune” and “genomic” surveillance pathways has been characterized. It appears that immune mechanisms may contribute to the effects of common cancer risk factors. We provide an updated overview of evidence for cancer immune surveillance, cancer risk factors interfering with it, and interventions to enhance cancer immune surveillance as tools to complement ongoing vaccine development efforts for cancer immunoprevention. Although there is a lot of support for cancer immunoprevention with simple lifestyle modifications from observational studies, there is an urgent need for clinical trials to establish the effectiveness of this approach for public health benefits. Frontiers Media S.A. 2017-05-08 /pmc/articles/PMC5421153/ /pubmed/28534024 http://dx.doi.org/10.3389/fpubh.2017.00101 Text en Copyright © 2017 Singh and Dorak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Singh, Sandeep K.
Dorak, Mehmet Tevfik
Cancer Immunoprevention and Public Health
title Cancer Immunoprevention and Public Health
title_full Cancer Immunoprevention and Public Health
title_fullStr Cancer Immunoprevention and Public Health
title_full_unstemmed Cancer Immunoprevention and Public Health
title_short Cancer Immunoprevention and Public Health
title_sort cancer immunoprevention and public health
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421153/
https://www.ncbi.nlm.nih.gov/pubmed/28534024
http://dx.doi.org/10.3389/fpubh.2017.00101
work_keys_str_mv AT singhsandeepk cancerimmunopreventionandpublichealth
AT dorakmehmettevfik cancerimmunopreventionandpublichealth