Challenges and emerging directions in single-cell analysis

Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enabled systematic investigation of cellular heterogeneity in a wide range of tissues and cell po...

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Autores principales: Yuan, Guo-Cheng, Cai, Long, Elowitz, Michael, Enver, Tariq, Fan, Guoping, Guo, Guoji, Irizarry, Rafael, Kharchenko, Peter, Kim, Junhyong, Orkin, Stuart, Quackenbush, John, Saadatpour, Assieh, Schroeder, Timm, Shivdasani, Ramesh, Tirosh, Itay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Open Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421338/
https://www.ncbi.nlm.nih.gov/pubmed/28482897
http://dx.doi.org/10.1186/s13059-017-1218-y
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author Yuan, Guo-Cheng
Cai, Long
Elowitz, Michael
Enver, Tariq
Fan, Guoping
Guo, Guoji
Irizarry, Rafael
Kharchenko, Peter
Kim, Junhyong
Orkin, Stuart
Quackenbush, John
Saadatpour, Assieh
Schroeder, Timm
Shivdasani, Ramesh
Tirosh, Itay
author_facet Yuan, Guo-Cheng
Cai, Long
Elowitz, Michael
Enver, Tariq
Fan, Guoping
Guo, Guoji
Irizarry, Rafael
Kharchenko, Peter
Kim, Junhyong
Orkin, Stuart
Quackenbush, John
Saadatpour, Assieh
Schroeder, Timm
Shivdasani, Ramesh
Tirosh, Itay
author_sort Yuan, Guo-Cheng
collection PubMed
description Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enabled systematic investigation of cellular heterogeneity in a wide range of tissues and cell populations, yielding fresh insights into the composition, dynamics, and regulatory mechanisms of cell states in development and disease. Despite substantial advances, significant challenges remain in the analysis, integration, and interpretation of single-cell omics data. Here, we discuss the state of the field and recent advances and look to future opportunities.
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spelling pubmed-54213382017-05-12 Challenges and emerging directions in single-cell analysis Yuan, Guo-Cheng Cai, Long Elowitz, Michael Enver, Tariq Fan, Guoping Guo, Guoji Irizarry, Rafael Kharchenko, Peter Kim, Junhyong Orkin, Stuart Quackenbush, John Saadatpour, Assieh Schroeder, Timm Shivdasani, Ramesh Tirosh, Itay Genome Biol Open Letter Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enabled systematic investigation of cellular heterogeneity in a wide range of tissues and cell populations, yielding fresh insights into the composition, dynamics, and regulatory mechanisms of cell states in development and disease. Despite substantial advances, significant challenges remain in the analysis, integration, and interpretation of single-cell omics data. Here, we discuss the state of the field and recent advances and look to future opportunities. BioMed Central 2017-05-08 /pmc/articles/PMC5421338/ /pubmed/28482897 http://dx.doi.org/10.1186/s13059-017-1218-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Open Letter
Yuan, Guo-Cheng
Cai, Long
Elowitz, Michael
Enver, Tariq
Fan, Guoping
Guo, Guoji
Irizarry, Rafael
Kharchenko, Peter
Kim, Junhyong
Orkin, Stuart
Quackenbush, John
Saadatpour, Assieh
Schroeder, Timm
Shivdasani, Ramesh
Tirosh, Itay
Challenges and emerging directions in single-cell analysis
title Challenges and emerging directions in single-cell analysis
title_full Challenges and emerging directions in single-cell analysis
title_fullStr Challenges and emerging directions in single-cell analysis
title_full_unstemmed Challenges and emerging directions in single-cell analysis
title_short Challenges and emerging directions in single-cell analysis
title_sort challenges and emerging directions in single-cell analysis
topic Open Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421338/
https://www.ncbi.nlm.nih.gov/pubmed/28482897
http://dx.doi.org/10.1186/s13059-017-1218-y
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