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Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is associated with a high risk of Alzheimer’s di...

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Detalles Bibliográficos
Autores principales:	Benn, Marianne, Nordestgaard, Børge G, Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group Ltd. 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421439/ https://www.ncbi.nlm.nih.gov/pubmed/28438747 http://dx.doi.org/10.1136/bmj.j1648

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