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Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease

BACKGROUND: The knowledge of the variables predicting mortality is important in clinical practice and for therapeutic monitoring in mitral valve disease. OBJECTIVES: To determine whether a quality of life score evaluated with the Functional Evaluation of Cardiac Health questionnaire would predict mo...

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Autores principales: Strunz, Célia M. C., Marcondes-Santos, Mário, Takada, Julio Yoshio, Fragata, Fernanda S., Mansur, Antônio de Pádua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421474/
https://www.ncbi.nlm.nih.gov/pubmed/28380134
http://dx.doi.org/10.5935/abc.20170032
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author Strunz, Célia M. C.
Marcondes-Santos, Mário
Takada, Julio Yoshio
Fragata, Fernanda S.
Mansur, Antônio de Pádua
author_facet Strunz, Célia M. C.
Marcondes-Santos, Mário
Takada, Julio Yoshio
Fragata, Fernanda S.
Mansur, Antônio de Pádua
author_sort Strunz, Célia M. C.
collection PubMed
description BACKGROUND: The knowledge of the variables predicting mortality is important in clinical practice and for therapeutic monitoring in mitral valve disease. OBJECTIVES: To determine whether a quality of life score evaluated with the Functional Evaluation of Cardiac Health questionnaire would predict mortality in dogs with degenerative mitral valve disease (DMVD). METHODS: Thirty-six client-owned dogs with mitral valve disease underwent clinical, laboratory, and echocardiographic evaluations at baseline and were monitored for 6 months. Cardiovascular death was the primary outcome. RESULTS: The 36 dogs were classified as survivors or nonsurvivors. Higher values of the following variables were obtained at baseline in the nonsurviving group (12 dogs): amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, plasma norepinephrine, heart rate, quality of life score, diastolic left ventricular internal dimension to aortic root ratio, systolic left ventricular internal dimension to aortic root ratio, and left atrium to aortic root ratio. NT-proBNP levels and quality life score were independently associated with death in the multivariable analysis. CONCLUSION: The quality life score was an independent variable for cardiac death in dogs with DMVD. This result is encouraging, as this score is easy to apply and does not require any technology, only a veterinarian and an observant owner.
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spelling pubmed-54214742017-05-11 Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease Strunz, Célia M. C. Marcondes-Santos, Mário Takada, Julio Yoshio Fragata, Fernanda S. Mansur, Antônio de Pádua Arq Bras Cardiol Original Articles BACKGROUND: The knowledge of the variables predicting mortality is important in clinical practice and for therapeutic monitoring in mitral valve disease. OBJECTIVES: To determine whether a quality of life score evaluated with the Functional Evaluation of Cardiac Health questionnaire would predict mortality in dogs with degenerative mitral valve disease (DMVD). METHODS: Thirty-six client-owned dogs with mitral valve disease underwent clinical, laboratory, and echocardiographic evaluations at baseline and were monitored for 6 months. Cardiovascular death was the primary outcome. RESULTS: The 36 dogs were classified as survivors or nonsurvivors. Higher values of the following variables were obtained at baseline in the nonsurviving group (12 dogs): amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, plasma norepinephrine, heart rate, quality of life score, diastolic left ventricular internal dimension to aortic root ratio, systolic left ventricular internal dimension to aortic root ratio, and left atrium to aortic root ratio. NT-proBNP levels and quality life score were independently associated with death in the multivariable analysis. CONCLUSION: The quality life score was an independent variable for cardiac death in dogs with DMVD. This result is encouraging, as this score is easy to apply and does not require any technology, only a veterinarian and an observant owner. Sociedade Brasileira de Cardiologia - SBC 2017-04 /pmc/articles/PMC5421474/ /pubmed/28380134 http://dx.doi.org/10.5935/abc.20170032 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Strunz, Célia M. C.
Marcondes-Santos, Mário
Takada, Julio Yoshio
Fragata, Fernanda S.
Mansur, Antônio de Pádua
Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title_full Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title_fullStr Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title_full_unstemmed Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title_short Quality of Life Score as a Predictor of Death in Dogs with Degenerative Mitral Valve Disease
title_sort quality of life score as a predictor of death in dogs with degenerative mitral valve disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421474/
https://www.ncbi.nlm.nih.gov/pubmed/28380134
http://dx.doi.org/10.5935/abc.20170032
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