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Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome
Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications suc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421487/ https://www.ncbi.nlm.nih.gov/pubmed/28515823 http://dx.doi.org/10.14740/cr534e |
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author | Murtaza, Ghulam Iskandar, Joy Humphrey, Tara Adhikari, Sujeen Kuruvilla, Aneesh |
author_facet | Murtaza, Ghulam Iskandar, Joy Humphrey, Tara Adhikari, Sujeen Kuruvilla, Aneesh |
author_sort | Murtaza, Ghulam |
collection | PubMed |
description | Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications such as cardiac failure, arrhythmias, and thromboembolic events. Recently, association of Libman-Sacks endocarditis with antiphospholipid antibody syndrome (APS) has been made. APS is most commonly defined by venous and arterial thrombosis, recurrent pregnancy loss, and thrombocytopenia. While the syndrome can be a primary syndrome, it is usually secondary to systemic lupus erythematosus. Catastrophic antiphospholipid syndrome (CAPS) can be a life-threatening presentation of APS and can occur in 1% of patients with antiphospholipid syndrome. We present a very rare case of a young female patient with lupus-negative Libman-Sacks endocarditis complicated by CAPS. |
format | Online Article Text |
id | pubmed-5421487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54214872017-05-17 Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome Murtaza, Ghulam Iskandar, Joy Humphrey, Tara Adhikari, Sujeen Kuruvilla, Aneesh Cardiol Res Case Report Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications such as cardiac failure, arrhythmias, and thromboembolic events. Recently, association of Libman-Sacks endocarditis with antiphospholipid antibody syndrome (APS) has been made. APS is most commonly defined by venous and arterial thrombosis, recurrent pregnancy loss, and thrombocytopenia. While the syndrome can be a primary syndrome, it is usually secondary to systemic lupus erythematosus. Catastrophic antiphospholipid syndrome (CAPS) can be a life-threatening presentation of APS and can occur in 1% of patients with antiphospholipid syndrome. We present a very rare case of a young female patient with lupus-negative Libman-Sacks endocarditis complicated by CAPS. Elmer Press 2017-04 2017-05-03 /pmc/articles/PMC5421487/ /pubmed/28515823 http://dx.doi.org/10.14740/cr534e Text en Copyright 2017, Murtaza et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Murtaza, Ghulam Iskandar, Joy Humphrey, Tara Adhikari, Sujeen Kuruvilla, Aneesh Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title | Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title_full | Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title_fullStr | Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title_full_unstemmed | Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title_short | Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome |
title_sort | lupus-negative libman-sacks endocarditis complicated by catastrophic antiphospholipid syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421487/ https://www.ncbi.nlm.nih.gov/pubmed/28515823 http://dx.doi.org/10.14740/cr534e |
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