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NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ(42,) in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents

INTRODUCTION: Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years. METHODS: Using amyloid biomarkers, chemical modeling, mouse behavioral models, and drug development techniques...

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Detalles Bibliográficos
Autores principales:	Kounnas, Maria Z., Lane-Donovan, Courtney, Nowakowski, Dan W., Herz, Joachim, Comer, William T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421551/ https://www.ncbi.nlm.nih.gov/pubmed/28497107 http://dx.doi.org/10.1016/j.trci.2016.09.003

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