Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the improvement of overall survival. Intratumoral hetero...

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Detalles Bibliográficos
Autores principales: Weitsman, G, Mitchell, N J, Evans, R, Cheung, A, Kalber, T L, Bofinger, R, Fruhwirth, G O, Keppler, M, Wright, Z V F, Barber, P R, Gordon, P, de Koning, T, Wulaningsih, W, Sander, K, Vojnovic, B, Ameer-Beg, S, Lythgoe, M, Arnold, J N, Årstad, E, Festy, F, Hailes, H C, Tabor, A B, Ng, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421598/
https://www.ncbi.nlm.nih.gov/pubmed/28166195
http://dx.doi.org/10.1038/onc.2016.522

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