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Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor
BACKGROUND/OBJECTIVES: Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we col...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421780/ https://www.ncbi.nlm.nih.gov/pubmed/28481950 http://dx.doi.org/10.1371/journal.pone.0177327 |
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author | Tsutsumi, Joshi Minai, Kosuke Kawai, Makoto Ogawa, Kazuo Inoue, Yasunori Morimoto, Satoshi Tanaka, Toshikazu Nagoshi, Tomohisa Ogawa, Takayuki Yoshimura, Michihiro |
author_facet | Tsutsumi, Joshi Minai, Kosuke Kawai, Makoto Ogawa, Kazuo Inoue, Yasunori Morimoto, Satoshi Tanaka, Toshikazu Nagoshi, Tomohisa Ogawa, Takayuki Yoshimura, Michihiro |
author_sort | Tsutsumi, Joshi |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients. METHODS AND RESULTS: The study patients consisted of 1252 subjects (IHD: n = 970; non-IHD: n = 282). Multiple logistic regression analysis revealed that dyslipidemia, hypertension, diabetes, and the low reactivity of BNP were significant risk factors for IHD, but body mass index (BMI) was not. A theoretical path model was proposed by positioning BMI at the top of the hierarchical model. Exploratory factor analysis revealed that BMI did not play a causative role in IHD (P = NS). BMI was causatively linked to other risk factors (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP), and these factors played a causative role in IHD (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP). The intrinsic power of the low reactivity of BNP induced by high BMI on the promotion of IHD was fairly potent. CONCLUSION: This study demonstrated that obesity per se is not a strong risk factor for IHD in Japanese patients. However, several important risk factors triggered by obesity exhibited a causative role for IHD. The low reactivity of BNP is a substantial risk factor for IHD. |
format | Online Article Text |
id | pubmed-5421780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54217802017-05-14 Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor Tsutsumi, Joshi Minai, Kosuke Kawai, Makoto Ogawa, Kazuo Inoue, Yasunori Morimoto, Satoshi Tanaka, Toshikazu Nagoshi, Tomohisa Ogawa, Takayuki Yoshimura, Michihiro PLoS One Research Article BACKGROUND/OBJECTIVES: Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients. METHODS AND RESULTS: The study patients consisted of 1252 subjects (IHD: n = 970; non-IHD: n = 282). Multiple logistic regression analysis revealed that dyslipidemia, hypertension, diabetes, and the low reactivity of BNP were significant risk factors for IHD, but body mass index (BMI) was not. A theoretical path model was proposed by positioning BMI at the top of the hierarchical model. Exploratory factor analysis revealed that BMI did not play a causative role in IHD (P = NS). BMI was causatively linked to other risk factors (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP), and these factors played a causative role in IHD (P<0.001 for hypertension; P<0.001 for dyslipidemia; P<0.001 for HbA1c; P<0.001 for LogBNP). The intrinsic power of the low reactivity of BNP induced by high BMI on the promotion of IHD was fairly potent. CONCLUSION: This study demonstrated that obesity per se is not a strong risk factor for IHD in Japanese patients. However, several important risk factors triggered by obesity exhibited a causative role for IHD. The low reactivity of BNP is a substantial risk factor for IHD. Public Library of Science 2017-05-08 /pmc/articles/PMC5421780/ /pubmed/28481950 http://dx.doi.org/10.1371/journal.pone.0177327 Text en © 2017 Tsutsumi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tsutsumi, Joshi Minai, Kosuke Kawai, Makoto Ogawa, Kazuo Inoue, Yasunori Morimoto, Satoshi Tanaka, Toshikazu Nagoshi, Tomohisa Ogawa, Takayuki Yoshimura, Michihiro Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title | Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title_full | Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title_fullStr | Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title_full_unstemmed | Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title_short | Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor |
title_sort | manifold implications of obesity in ischemic heart disease among japanese patients according to covariance structure analysis: low reactivity of b-type natriuretic peptide as an intervening risk factor |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421780/ https://www.ncbi.nlm.nih.gov/pubmed/28481950 http://dx.doi.org/10.1371/journal.pone.0177327 |
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