The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus

Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show that Kif7 is required for normal T-cell development, despite the fact that T-cells lack primary cilia. Analysis of Kif7-deficient thymus show...

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Detalles Bibliográficos
Autores principales: Lau, Ching-In, Barbarulo, Alessandro, Solanki, Anisha, Saldaña, José Ignacio, Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421836/
https://www.ncbi.nlm.nih.gov/pubmed/28445929
http://dx.doi.org/10.18632/oncotarget.15241

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