Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population

Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population...

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Autores principales: Zhang, Ning, Wu, Yishuo, Gong, Jian, Li, Kaiwen, Lin, Xiaolin, Chen, Haitao, Yu, Yang, Gou, Yuancheng, Hou, Jiangang, Jiang, Deke, Na, Rong, Wang, Xiang, Ding, Qiang, Xu, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
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Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421839/
https://www.ncbi.nlm.nih.gov/pubmed/26918600
http://dx.doi.org/10.18632/oncotarget.6917
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author Zhang, Ning
Wu, Yishuo
Gong, Jian
Li, Kaiwen
Lin, Xiaolin
Chen, Haitao
Yu, Yang
Gou, Yuancheng
Hou, Jiangang
Jiang, Deke
Na, Rong
Wang, Xiang
Ding, Qiang
Xu, Jianfeng
author_facet Zhang, Ning
Wu, Yishuo
Gong, Jian
Li, Kaiwen
Lin, Xiaolin
Chen, Haitao
Yu, Yang
Gou, Yuancheng
Hou, Jiangang
Jiang, Deke
Na, Rong
Wang, Xiang
Ding, Qiang
Xu, Jianfeng
author_sort Zhang, Ning
collection PubMed
description Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC risk-associated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26 × 10(−8)) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population.
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spelling pubmed-54218392017-05-10 Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population Zhang, Ning Wu, Yishuo Gong, Jian Li, Kaiwen Lin, Xiaolin Chen, Haitao Yu, Yang Gou, Yuancheng Hou, Jiangang Jiang, Deke Na, Rong Wang, Xiang Ding, Qiang Xu, Jianfeng Oncotarget Research Paper Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC risk-associated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26 × 10(−8)) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population. Impact Journals LLC 2016-01-14 /pmc/articles/PMC5421839/ /pubmed/26918600 http://dx.doi.org/10.18632/oncotarget.6917 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Ning
Wu, Yishuo
Gong, Jian
Li, Kaiwen
Lin, Xiaolin
Chen, Haitao
Yu, Yang
Gou, Yuancheng
Hou, Jiangang
Jiang, Deke
Na, Rong
Wang, Xiang
Ding, Qiang
Xu, Jianfeng
Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title_full Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title_fullStr Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title_full_unstemmed Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title_short Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
title_sort germline genetic variations in pdzd2 and itpr2 genes are associated with clear cell renal cell carcinoma in chinese population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421839/
https://www.ncbi.nlm.nih.gov/pubmed/26918600
http://dx.doi.org/10.18632/oncotarget.6917
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