Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer

Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed i...

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Autores principales: Lin, Junhao, Zhan, Yonghao, Liu, Yuchen, Chen, Zhicong, Liang, Jianbo, Li, Wei, He, Anbang, Zhou, Liqun, Mei, Hongbin, Wang, Feng, Huang, Weiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421840/
https://www.ncbi.nlm.nih.gov/pubmed/28445936
http://dx.doi.org/10.18632/oncotarget.15527
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author Lin, Junhao
Zhan, Yonghao
Liu, Yuchen
Chen, Zhicong
Liang, Jianbo
Li, Wei
He, Anbang
Zhou, Liqun
Mei, Hongbin
Wang, Feng
Huang, Weiren
author_facet Lin, Junhao
Zhan, Yonghao
Liu, Yuchen
Chen, Zhicong
Liang, Jianbo
Li, Wei
He, Anbang
Zhou, Liqun
Mei, Hongbin
Wang, Feng
Huang, Weiren
author_sort Lin, Junhao
collection PubMed
description Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer.
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spelling pubmed-54218402017-05-10 Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer Lin, Junhao Zhan, Yonghao Liu, Yuchen Chen, Zhicong Liang, Jianbo Li, Wei He, Anbang Zhou, Liqun Mei, Hongbin Wang, Feng Huang, Weiren Oncotarget Research Paper Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer. Impact Journals LLC 2017-02-20 /pmc/articles/PMC5421840/ /pubmed/28445936 http://dx.doi.org/10.18632/oncotarget.15527 Text en Copyright: © 2017 Lin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lin, Junhao
Zhan, Yonghao
Liu, Yuchen
Chen, Zhicong
Liang, Jianbo
Li, Wei
He, Anbang
Zhou, Liqun
Mei, Hongbin
Wang, Feng
Huang, Weiren
Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title_full Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title_fullStr Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title_full_unstemmed Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title_short Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
title_sort increased expression of zeb1-as1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421840/
https://www.ncbi.nlm.nih.gov/pubmed/28445936
http://dx.doi.org/10.18632/oncotarget.15527
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