Radiosynthesis and validation of (±)-[(18)F]-3-fluoro-2-hydroxypropionate ([(18)F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors

Cancers develop metabolic strategies to cope with their microenvironment often characterized by hypoxia, limited nutrient bioavailability and exposure to anticancer treatments. Among these strategies, the metabolic symbiosis based on the exchange of lactate between hypoxic/glycolytic cancer cells th...

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Detalles Bibliográficos
Autores principales: Van Hée, Vincent F., Labar, Daniel, Dehon, Gwenaël, Grasso, Debora, Grégoire, Vincent, Muccioli, Giulio G, Frédérick, Raphaël, Sonveaux, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421858/
https://www.ncbi.nlm.nih.gov/pubmed/28107190
http://dx.doi.org/10.18632/oncotarget.14705

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