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Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study
In this study, we aimed to develop and validate nomograms for predicting long-term overall survival (OS) and cancer-specific survival (CSS) in major salivary gland cancer (MSGC) patients. These nomograms were developed using a retrospective cohort (N=4218) from the Surveillance, Epidemiology, and En...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421863/ https://www.ncbi.nlm.nih.gov/pubmed/28160551 http://dx.doi.org/10.18632/oncotarget.14905 |
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author | Li, Yun Ju, Jun Liu, Xiaoxiao Gao, Tao Wang, Zhidong Ni, Qianwei Ma, Chao Zhao, Zhenyan Ren, Yixiong Sun, Moyi |
author_facet | Li, Yun Ju, Jun Liu, Xiaoxiao Gao, Tao Wang, Zhidong Ni, Qianwei Ma, Chao Zhao, Zhenyan Ren, Yixiong Sun, Moyi |
author_sort | Li, Yun |
collection | PubMed |
description | In this study, we aimed to develop and validate nomograms for predicting long-term overall survival (OS) and cancer-specific survival (CSS) in major salivary gland cancer (MSGC) patients. These nomograms were developed using a retrospective cohort (N=4218) from the Surveillance, Epidemiology, and End Results (SEER) database, and externally validated using an independent data cohort (N=244). We used univariate, and multivariate analyses, and cumulative incidence function to select the independent prognostic factors of OS and CSS. Index of concordance (c-index) and calibration plots were used to estimate the nomograms’ predictive accuracy. The median follow-up period was 34 months (1–119 months). Of 4218 MSGC patients, 1320 (31.3%) died by the end of the follow-up; of these 1320 patients, 883 (20.9%) died of MSGC. The OS nomogram, which had a c-index of 0.817, was based on nine variables: age, sex, tumor site, tumor grade, surgery performed, radiation therapy and TNM classifications. The CSS nomogram, which had a c-index of 0.829, was based on the same nine variables plus race. External validation c-indexes were 0.829 and 0.807 for OS and CSS, respectively. Based on SEER database, we have developed nomograms predicting five- and eight-years OS and CSS for MSGC patients with perfect accuracy. These nomograms will help clinicians customize treatment and monitoring strategies in MSGC patients. |
format | Online Article Text |
id | pubmed-5421863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54218632017-05-10 Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study Li, Yun Ju, Jun Liu, Xiaoxiao Gao, Tao Wang, Zhidong Ni, Qianwei Ma, Chao Zhao, Zhenyan Ren, Yixiong Sun, Moyi Oncotarget Research Paper In this study, we aimed to develop and validate nomograms for predicting long-term overall survival (OS) and cancer-specific survival (CSS) in major salivary gland cancer (MSGC) patients. These nomograms were developed using a retrospective cohort (N=4218) from the Surveillance, Epidemiology, and End Results (SEER) database, and externally validated using an independent data cohort (N=244). We used univariate, and multivariate analyses, and cumulative incidence function to select the independent prognostic factors of OS and CSS. Index of concordance (c-index) and calibration plots were used to estimate the nomograms’ predictive accuracy. The median follow-up period was 34 months (1–119 months). Of 4218 MSGC patients, 1320 (31.3%) died by the end of the follow-up; of these 1320 patients, 883 (20.9%) died of MSGC. The OS nomogram, which had a c-index of 0.817, was based on nine variables: age, sex, tumor site, tumor grade, surgery performed, radiation therapy and TNM classifications. The CSS nomogram, which had a c-index of 0.829, was based on the same nine variables plus race. External validation c-indexes were 0.829 and 0.807 for OS and CSS, respectively. Based on SEER database, we have developed nomograms predicting five- and eight-years OS and CSS for MSGC patients with perfect accuracy. These nomograms will help clinicians customize treatment and monitoring strategies in MSGC patients. Impact Journals LLC 2017-01-30 /pmc/articles/PMC5421863/ /pubmed/28160551 http://dx.doi.org/10.18632/oncotarget.14905 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Li, Yun Ju, Jun Liu, Xiaoxiao Gao, Tao Wang, Zhidong Ni, Qianwei Ma, Chao Zhao, Zhenyan Ren, Yixiong Sun, Moyi Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title_full | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title_fullStr | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title_full_unstemmed | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title_short | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
title_sort | nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421863/ https://www.ncbi.nlm.nih.gov/pubmed/28160551 http://dx.doi.org/10.18632/oncotarget.14905 |
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