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Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models
Mammalian Target of Rapamycin complex 2 (mTORC2) and its regulatory component Rapamycin-insensitive companion of mTOR (RICTOR) are increasingly recognized as important players in human cancer development and progression. However, the role of RICTOR in human pancreatic ductal adenocarcinoma (PDAC) is...
Autores principales: | Schmidt, Katharina M., Hellerbrand, Claus, Ruemmele, Petra, Michalski, Christoph W., Kong, Bo, Kroemer, Alexander, Hackl, Christina, Schlitt, Hans J., Geissler, Edward K., Lang, Sven A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421865/ https://www.ncbi.nlm.nih.gov/pubmed/28445935 http://dx.doi.org/10.18632/oncotarget.15524 |
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