Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity

Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked to rapid changes in epigenetic modifications, including increased histone me...

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Detalles Bibliográficos
Autores principales: Gursoy-Yuzugullu, Ozge, Carman, Chelsea, Serafim, Rodolfo Bortolozo, Myronakis, Marios, Valente, Valeria, Price, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421867/
https://www.ncbi.nlm.nih.gov/pubmed/28445939
http://dx.doi.org/10.18632/oncotarget.15543

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