A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients

The currently known Mendelian colorectal cancer (CRC) predisposition syndromes account for ∼5–10% of all CRC cases, and are caused by inherited germline mutations in single CRC predisposing genes. Using molecular inversion probes (MIPs), we designed a targeted next-generation sequencing panel to ide...

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Detalles Bibliográficos
Autores principales: Zhang, Junxiao, Wang, Xiaoyan, de Voer, Richarda M, Hehir-Kwa, Jayne Y., Kamping, Eveline J, Weren, Robbert D.A., Nelen, Marcel, Hoischen, Alexander, Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, Yang, Xiangling, Yang, Zihuan, Fan, Xinjuan, Wang, Lei, Liu, Huanliang, Wang, Jianping, Kuiper, Roland P., van Kessel, Ad Geurts
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421868/
https://www.ncbi.nlm.nih.gov/pubmed/28445943
http://dx.doi.org/10.18632/oncotarget.15593

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