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Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
Anaplastic thyroid cancers and radioiodine resistant thyroid cancer are posing a major treat since surgery combined with Iodine(131) therapy is ineffective on them. Small-molecule inhibitors are presenting a new hope for patients, but often lead to drug resistance in many cancers. Based on the major...
Autores principales: | ElMokh, Oussama, Ruffieux-Daidié, Dorothée, Roelli, Matthias A, Stooss, Amandine, Phillips, Wayne A, Gertsch, Jürg, Dettmer, Matthias S, Charles, Roch-Philippe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421873/ https://www.ncbi.nlm.nih.gov/pubmed/28445948 http://dx.doi.org/10.18632/oncotarget.15599 |
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