Cargando…

The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study

Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual screening. It exhibits stronger potency (...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Yuanyuan, Li, Linhu, Yang, Zhaoyong, Liu, Mingliang, Guo, Huiyuan, Shen, Weiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421875/
https://www.ncbi.nlm.nih.gov/pubmed/28445950
http://dx.doi.org/10.18632/oncotarget.15601