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The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study
Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual screening. It exhibits stronger potency (...
Autores principales: | Jin, Yuanyuan, Li, Linhu, Yang, Zhaoyong, Liu, Mingliang, Guo, Huiyuan, Shen, Weiyi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421875/ https://www.ncbi.nlm.nih.gov/pubmed/28445950 http://dx.doi.org/10.18632/oncotarget.15601 |
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