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The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study

Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual screening. It exhibits stronger potency (...

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Detalles Bibliográficos
Autores principales:	Jin, Yuanyuan, Li, Linhu, Yang, Zhaoyong, Liu, Mingliang, Guo, Huiyuan, Shen, Weiyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421875/ https://www.ncbi.nlm.nih.gov/pubmed/28445950 http://dx.doi.org/10.18632/oncotarget.15601

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