IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer

Recent studies explored the association between insulin receptor substrate-2 (IRS-2) gene rs1805097 polymorphism and colorectal cancer (CRC) with contradictory findings. Therefore, we conducted a comprehensive meta-analysis by searching the databases of PubMed and Embase. Pooled odds ratios (ORs) an...

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Detalles Bibliográficos
Autores principales: Yin, Jiefeng, Zhang, Zhe, Zheng, Huajun, Xu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421913/
https://www.ncbi.nlm.nih.gov/pubmed/28212577
http://dx.doi.org/10.18632/oncotarget.15342
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author Yin, Jiefeng
Zhang, Zhe
Zheng, Huajun
Xu, Lei
author_facet Yin, Jiefeng
Zhang, Zhe
Zheng, Huajun
Xu, Lei
author_sort Yin, Jiefeng
collection PubMed
description Recent studies explored the association between insulin receptor substrate-2 (IRS-2) gene rs1805097 polymorphism and colorectal cancer (CRC) with contradictory findings. Therefore, we conducted a comprehensive meta-analysis by searching the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 5 citations containing 6 case-control studies involving 4,333 cases and 5,333 controls were included. Our data indicated that IRS-2 rs1805097 polymorphism was associated with decreased risk of CRC. Stratification analysis of ethnicity found that rs1805097 polymorphism decreased the risk of CRC among Americans. Stratification analysis of cancer type suggested that this polymorphism decreased the risk of colon cancer. In summary, this meta-analysis indicates that IRS-2 gene rs1805097 polymorphism plays an important role in the pathogenesis of CRC.
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spelling pubmed-54219132017-05-10 IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer Yin, Jiefeng Zhang, Zhe Zheng, Huajun Xu, Lei Oncotarget Research Paper Recent studies explored the association between insulin receptor substrate-2 (IRS-2) gene rs1805097 polymorphism and colorectal cancer (CRC) with contradictory findings. Therefore, we conducted a comprehensive meta-analysis by searching the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 5 citations containing 6 case-control studies involving 4,333 cases and 5,333 controls were included. Our data indicated that IRS-2 rs1805097 polymorphism was associated with decreased risk of CRC. Stratification analysis of ethnicity found that rs1805097 polymorphism decreased the risk of CRC among Americans. Stratification analysis of cancer type suggested that this polymorphism decreased the risk of colon cancer. In summary, this meta-analysis indicates that IRS-2 gene rs1805097 polymorphism plays an important role in the pathogenesis of CRC. Impact Journals LLC 2017-02-15 /pmc/articles/PMC5421913/ /pubmed/28212577 http://dx.doi.org/10.18632/oncotarget.15342 Text en Copyright: © 2017 Yin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yin, Jiefeng
Zhang, Zhe
Zheng, Huajun
Xu, Lei
IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title_full IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title_fullStr IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title_full_unstemmed IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title_short IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
title_sort irs-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421913/
https://www.ncbi.nlm.nih.gov/pubmed/28212577
http://dx.doi.org/10.18632/oncotarget.15342
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