TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells

TMPRSS2:ERG (T/E) gene fusions are present in approximately 50% of all prostate cancer (PCa) cases. The expression of fusion mRNAs from distinct T/E variants is associated with clinicopathological parameters, while the underlying molecular processes remain unclear. We characterized the molecular mec...

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Detalles Bibliográficos
Autores principales: Ratz, Leonie, Laible, Mark, Kacprzyk, Lukasz A, Wittig-Blaich, Stephanie M, Tolstov, Yanis, Duensing, Stefan, Altevogt, Peter, Klauck, Sabine M, Sültmann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421914/
https://www.ncbi.nlm.nih.gov/pubmed/28445989
http://dx.doi.org/10.18632/oncotarget.15931

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