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Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy
AIMS: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients. METHODS...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421915/ https://www.ncbi.nlm.nih.gov/pubmed/28212578 http://dx.doi.org/10.18632/oncotarget.15349 |
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author | Aleksova, Aneta Beltrami, Antonio Paolo Carriere, Cosimo Barbati, Giulia Lesizza, Pierluigi Perrieri-Montanino, Martina Isola, Miriam Gentile, Piero Salvioni, Elisabetta Not, Tarcisio Agostoni, Piergiuseppe Sinagra, Gianfranco |
author_facet | Aleksova, Aneta Beltrami, Antonio Paolo Carriere, Cosimo Barbati, Giulia Lesizza, Pierluigi Perrieri-Montanino, Martina Isola, Miriam Gentile, Piero Salvioni, Elisabetta Not, Tarcisio Agostoni, Piergiuseppe Sinagra, Gianfranco |
author_sort | Aleksova, Aneta |
collection | PubMed |
description | AIMS: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients. METHODS AND RESULTS: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1.08 pg/mL, median IL-6 1.7 pg/mL and median IL-10 2.7 pg/mL). During the follow-up period of 89.6 months, 35 patients (22%) died/underwent heart transplantation. Patients who died/underwent heart transplantation were more likely to be male, to be in NYHA class III, to have atrial fibrillation, to have lower LVEF and higher BNP levels. IL-1β, IL-6 and IL-10 levels did not differ significantly between the groups of patients with good or bad prognosis. IL-1β levels did not vary significantly among either the different NYHA classes or the quartiles of LVEF. In a multivariable model, however, IL-1β was a strong and independent predictor of all-cause mortality (HR 1.193, 95% CI 1.056 – 1.349, p=0.005 for log squared transformed values). Other factors associated with the outcome were: male gender, presence of atrial fibrillation and sodium concentration. The estimated time-dependent ROC curve of the multivariable model showed an AUC 0.74 (95% CI 0.65-0.86). CONCLUSIONS: Serum levels of IL-1β could be useful to predict the long-term outcome of patients with iDCM. |
format | Online Article Text |
id | pubmed-5421915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54219152017-05-10 Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy Aleksova, Aneta Beltrami, Antonio Paolo Carriere, Cosimo Barbati, Giulia Lesizza, Pierluigi Perrieri-Montanino, Martina Isola, Miriam Gentile, Piero Salvioni, Elisabetta Not, Tarcisio Agostoni, Piergiuseppe Sinagra, Gianfranco Oncotarget Research Paper AIMS: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients. METHODS AND RESULTS: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1.08 pg/mL, median IL-6 1.7 pg/mL and median IL-10 2.7 pg/mL). During the follow-up period of 89.6 months, 35 patients (22%) died/underwent heart transplantation. Patients who died/underwent heart transplantation were more likely to be male, to be in NYHA class III, to have atrial fibrillation, to have lower LVEF and higher BNP levels. IL-1β, IL-6 and IL-10 levels did not differ significantly between the groups of patients with good or bad prognosis. IL-1β levels did not vary significantly among either the different NYHA classes or the quartiles of LVEF. In a multivariable model, however, IL-1β was a strong and independent predictor of all-cause mortality (HR 1.193, 95% CI 1.056 – 1.349, p=0.005 for log squared transformed values). Other factors associated with the outcome were: male gender, presence of atrial fibrillation and sodium concentration. The estimated time-dependent ROC curve of the multivariable model showed an AUC 0.74 (95% CI 0.65-0.86). CONCLUSIONS: Serum levels of IL-1β could be useful to predict the long-term outcome of patients with iDCM. Impact Journals LLC 2017-02-15 /pmc/articles/PMC5421915/ /pubmed/28212578 http://dx.doi.org/10.18632/oncotarget.15349 Text en Copyright: © 2017 Aleksova et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Aleksova, Aneta Beltrami, Antonio Paolo Carriere, Cosimo Barbati, Giulia Lesizza, Pierluigi Perrieri-Montanino, Martina Isola, Miriam Gentile, Piero Salvioni, Elisabetta Not, Tarcisio Agostoni, Piergiuseppe Sinagra, Gianfranco Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title | Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title_full | Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title_fullStr | Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title_full_unstemmed | Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title_short | Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
title_sort | interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421915/ https://www.ncbi.nlm.nih.gov/pubmed/28212578 http://dx.doi.org/10.18632/oncotarget.15349 |
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