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The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for end...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421929/ https://www.ncbi.nlm.nih.gov/pubmed/28445972 http://dx.doi.org/10.18632/oncotarget.15805 |
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author | Yang, Xiaojing Ren, Hanru Sun, Yi Zhang, Lihua Yang, Xinmiao Li, Hongling Shao, Yuhui Fu, Jie |
author_facet | Yang, Xiaojing Ren, Hanru Sun, Yi Zhang, Lihua Yang, Xinmiao Li, Hongling Shao, Yuhui Fu, Jie |
author_sort | Yang, Xiaojing |
collection | PubMed |
description | Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1. Cox regression and log-rank tests were used to evaluate the D-dimer levels in relation to progression free survival (PFS) and overall survival (OS). The OS and PFS of patients with a low D1 were significantly longer than those with a high D1 (P< 0.001, P< 0.001). We saw the similar correlation between D2, PFS and OS (P< 0.001, P< 0.001). Multivariate survival analyses showed that D-dimer was independently associated with OS and PFS in patients with endometrial cancer. The ΔD level was not related to the OS and PFS in endometrial cancer patients. The levels of D-dimer may be considered as an important predictor of PFS and OS in endometrial cancer patients treated with IMRT. |
format | Online Article Text |
id | pubmed-5421929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54219292017-05-10 The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy Yang, Xiaojing Ren, Hanru Sun, Yi Zhang, Lihua Yang, Xinmiao Li, Hongling Shao, Yuhui Fu, Jie Oncotarget Research Paper Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1. Cox regression and log-rank tests were used to evaluate the D-dimer levels in relation to progression free survival (PFS) and overall survival (OS). The OS and PFS of patients with a low D1 were significantly longer than those with a high D1 (P< 0.001, P< 0.001). We saw the similar correlation between D2, PFS and OS (P< 0.001, P< 0.001). Multivariate survival analyses showed that D-dimer was independently associated with OS and PFS in patients with endometrial cancer. The ΔD level was not related to the OS and PFS in endometrial cancer patients. The levels of D-dimer may be considered as an important predictor of PFS and OS in endometrial cancer patients treated with IMRT. Impact Journals LLC 2017-02-28 /pmc/articles/PMC5421929/ /pubmed/28445972 http://dx.doi.org/10.18632/oncotarget.15805 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yang, Xiaojing Ren, Hanru Sun, Yi Zhang, Lihua Yang, Xinmiao Li, Hongling Shao, Yuhui Fu, Jie The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title | The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title_full | The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title_fullStr | The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title_full_unstemmed | The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title_short | The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
title_sort | prognostic value of d-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421929/ https://www.ncbi.nlm.nih.gov/pubmed/28445972 http://dx.doi.org/10.18632/oncotarget.15805 |
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