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The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy

Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for end...

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Autores principales: Yang, Xiaojing, Ren, Hanru, Sun, Yi, Zhang, Lihua, Yang, Xinmiao, Li, Hongling, Shao, Yuhui, Fu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421929/
https://www.ncbi.nlm.nih.gov/pubmed/28445972
http://dx.doi.org/10.18632/oncotarget.15805
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author Yang, Xiaojing
Ren, Hanru
Sun, Yi
Zhang, Lihua
Yang, Xinmiao
Li, Hongling
Shao, Yuhui
Fu, Jie
author_facet Yang, Xiaojing
Ren, Hanru
Sun, Yi
Zhang, Lihua
Yang, Xinmiao
Li, Hongling
Shao, Yuhui
Fu, Jie
author_sort Yang, Xiaojing
collection PubMed
description Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1. Cox regression and log-rank tests were used to evaluate the D-dimer levels in relation to progression free survival (PFS) and overall survival (OS). The OS and PFS of patients with a low D1 were significantly longer than those with a high D1 (P< 0.001, P< 0.001). We saw the similar correlation between D2, PFS and OS (P< 0.001, P< 0.001). Multivariate survival analyses showed that D-dimer was independently associated with OS and PFS in patients with endometrial cancer. The ΔD level was not related to the OS and PFS in endometrial cancer patients. The levels of D-dimer may be considered as an important predictor of PFS and OS in endometrial cancer patients treated with IMRT.
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spelling pubmed-54219292017-05-10 The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy Yang, Xiaojing Ren, Hanru Sun, Yi Zhang, Lihua Yang, Xinmiao Li, Hongling Shao, Yuhui Fu, Jie Oncotarget Research Paper Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1. Cox regression and log-rank tests were used to evaluate the D-dimer levels in relation to progression free survival (PFS) and overall survival (OS). The OS and PFS of patients with a low D1 were significantly longer than those with a high D1 (P< 0.001, P< 0.001). We saw the similar correlation between D2, PFS and OS (P< 0.001, P< 0.001). Multivariate survival analyses showed that D-dimer was independently associated with OS and PFS in patients with endometrial cancer. The ΔD level was not related to the OS and PFS in endometrial cancer patients. The levels of D-dimer may be considered as an important predictor of PFS and OS in endometrial cancer patients treated with IMRT. Impact Journals LLC 2017-02-28 /pmc/articles/PMC5421929/ /pubmed/28445972 http://dx.doi.org/10.18632/oncotarget.15805 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yang, Xiaojing
Ren, Hanru
Sun, Yi
Zhang, Lihua
Yang, Xinmiao
Li, Hongling
Shao, Yuhui
Fu, Jie
The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title_full The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title_fullStr The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title_full_unstemmed The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title_short The prognostic value of D-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
title_sort prognostic value of d-dimer levels in endometrial cancer patients treated with intensity-modulated radiation therapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421929/
https://www.ncbi.nlm.nih.gov/pubmed/28445972
http://dx.doi.org/10.18632/oncotarget.15805
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