Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women

In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M...

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Detalles Bibliográficos
Autores principales: Wu, Junrong, Fang, Min, Zhou, Xiaoping, Zhu, Bo, Yang, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421936/
https://www.ncbi.nlm.nih.gov/pubmed/28445984
http://dx.doi.org/10.18632/oncotarget.15911
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author Wu, Junrong
Fang, Min
Zhou, Xiaoping
Zhu, Bo
Yang, Zhi
author_facet Wu, Junrong
Fang, Min
Zhou, Xiaoping
Zhu, Bo
Yang, Zhi
author_sort Wu, Junrong
collection PubMed
description In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M carrier status and M alleles, were associated with an increased risk of breast cancer. In addition, the M allele was associated with postmenopausal status and increased nodal involvement. In contrast, none of the Q192R genotypes or alleles were associated with a change in breast cancer risk, or with any of the clinicopathological parameters. These results indicate that PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.
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spelling pubmed-54219362017-05-10 Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women Wu, Junrong Fang, Min Zhou, Xiaoping Zhu, Bo Yang, Zhi Oncotarget Research Paper In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M carrier status and M alleles, were associated with an increased risk of breast cancer. In addition, the M allele was associated with postmenopausal status and increased nodal involvement. In contrast, none of the Q192R genotypes or alleles were associated with a change in breast cancer risk, or with any of the clinicopathological parameters. These results indicate that PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women. Impact Journals LLC 2017-03-06 /pmc/articles/PMC5421936/ /pubmed/28445984 http://dx.doi.org/10.18632/oncotarget.15911 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Junrong
Fang, Min
Zhou, Xiaoping
Zhu, Bo
Yang, Zhi
Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title_full Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title_fullStr Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title_full_unstemmed Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title_short Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women
title_sort paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of chinese women
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421936/
https://www.ncbi.nlm.nih.gov/pubmed/28445984
http://dx.doi.org/10.18632/oncotarget.15911
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