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The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time in force swim test and tail suspension test, but did not infl...

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Autores principales: Jiang, Xi, Zhu, Keqi, Xu, Quanyi, Wang, Guokang, Zhang, Jiajia, Cao, Rongrong, Ye, Jiang, Yu, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421950/
https://www.ncbi.nlm.nih.gov/pubmed/28424423
http://dx.doi.org/10.18632/oncotarget.16069
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author Jiang, Xi
Zhu, Keqi
Xu, Quanyi
Wang, Guokang
Zhang, Jiajia
Cao, Rongrong
Ye, Jiang
Yu, Xuefeng
author_facet Jiang, Xi
Zhu, Keqi
Xu, Quanyi
Wang, Guokang
Zhang, Jiajia
Cao, Rongrong
Ye, Jiang
Yu, Xuefeng
author_sort Jiang, Xi
collection PubMed
description The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time in force swim test and tail suspension test, but did not influence locomotor activity. Trans-astaxanthin treatment did not effectively antagonize hypothermia and ptosis induced by reserpine. However, pre-treatment with para-chlorophenylalanine abolished the anti-immobility effect of trans-astaxanthin in force swim and tail suspension test. These results suggested that the mechanism of antidepressant-like effect of trans-astaxanthin may involve the serotonergic system, but not noradrenaline system. This hypothesis was confirmed by neurochemical assays which showed that trans-astaxanthin increased serotonin levels in the hippocampus, frontal cortex, striatum and hypothalamus. Furthermore, our data suggested that trans-astaxanthin decreased indoleamine 2, 3-dioxygenase activity in the hippocampus, frontal cortex and hypothalamus. Inhibition of indoleamine 2,3-dioxygenase activity subsequently decreased the kynurenine/tryptophan ratio and increased the serotonin/tryptophan ratio in these brain regions. Taken together, these findings indicate that the antidepressant-like effect of trans-astaxanthin involves the serotonergic system.
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spelling pubmed-54219502017-05-10 The antidepressant-like effect of trans-astaxanthin involves the serotonergic system Jiang, Xi Zhu, Keqi Xu, Quanyi Wang, Guokang Zhang, Jiajia Cao, Rongrong Ye, Jiang Yu, Xuefeng Oncotarget Research Paper The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time in force swim test and tail suspension test, but did not influence locomotor activity. Trans-astaxanthin treatment did not effectively antagonize hypothermia and ptosis induced by reserpine. However, pre-treatment with para-chlorophenylalanine abolished the anti-immobility effect of trans-astaxanthin in force swim and tail suspension test. These results suggested that the mechanism of antidepressant-like effect of trans-astaxanthin may involve the serotonergic system, but not noradrenaline system. This hypothesis was confirmed by neurochemical assays which showed that trans-astaxanthin increased serotonin levels in the hippocampus, frontal cortex, striatum and hypothalamus. Furthermore, our data suggested that trans-astaxanthin decreased indoleamine 2, 3-dioxygenase activity in the hippocampus, frontal cortex and hypothalamus. Inhibition of indoleamine 2,3-dioxygenase activity subsequently decreased the kynurenine/tryptophan ratio and increased the serotonin/tryptophan ratio in these brain regions. Taken together, these findings indicate that the antidepressant-like effect of trans-astaxanthin involves the serotonergic system. Impact Journals LLC 2017-03-10 /pmc/articles/PMC5421950/ /pubmed/28424423 http://dx.doi.org/10.18632/oncotarget.16069 Text en Copyright: © 2017 Jiang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jiang, Xi
Zhu, Keqi
Xu, Quanyi
Wang, Guokang
Zhang, Jiajia
Cao, Rongrong
Ye, Jiang
Yu, Xuefeng
The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title_full The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title_fullStr The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title_full_unstemmed The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title_short The antidepressant-like effect of trans-astaxanthin involves the serotonergic system
title_sort antidepressant-like effect of trans-astaxanthin involves the serotonergic system
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421950/
https://www.ncbi.nlm.nih.gov/pubmed/28424423
http://dx.doi.org/10.18632/oncotarget.16069
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