Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities

The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, me...

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Autores principales: Xiong, Hanchu, Zhao, Wenhe, Wang, Ji, Seifer, Benjamin J., Ye, Chenyang, Chen, Yongxia, Jia, Yunlu, Chen, Cong, Shen, Jianguo, Wang, Linbo, Sui, Xinbing, Zhou, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421965/
https://www.ncbi.nlm.nih.gov/pubmed/28147339
http://dx.doi.org/10.18632/oncotarget.14891
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author Xiong, Hanchu
Zhao, Wenhe
Wang, Ji
Seifer, Benjamin J.
Ye, Chenyang
Chen, Yongxia
Jia, Yunlu
Chen, Cong
Shen, Jianguo
Wang, Linbo
Sui, Xinbing
Zhou, Jichun
author_facet Xiong, Hanchu
Zhao, Wenhe
Wang, Ji
Seifer, Benjamin J.
Ye, Chenyang
Chen, Yongxia
Jia, Yunlu
Chen, Cong
Shen, Jianguo
Wang, Linbo
Sui, Xinbing
Zhou, Jichun
author_sort Xiong, Hanchu
collection PubMed
description The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer.
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spelling pubmed-54219652017-05-10 Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities Xiong, Hanchu Zhao, Wenhe Wang, Ji Seifer, Benjamin J. Ye, Chenyang Chen, Yongxia Jia, Yunlu Chen, Cong Shen, Jianguo Wang, Linbo Sui, Xinbing Zhou, Jichun Oncotarget Review The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer. Impact Journals LLC 2017-01-29 /pmc/articles/PMC5421965/ /pubmed/28147339 http://dx.doi.org/10.18632/oncotarget.14891 Text en Copyright: © 2017 Xiong et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Xiong, Hanchu
Zhao, Wenhe
Wang, Ji
Seifer, Benjamin J.
Ye, Chenyang
Chen, Yongxia
Jia, Yunlu
Chen, Cong
Shen, Jianguo
Wang, Linbo
Sui, Xinbing
Zhou, Jichun
Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title_full Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title_fullStr Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title_full_unstemmed Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title_short Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
title_sort oncogenic mechanisms of lin28 in breast cancer: new functions and therapeutic opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421965/
https://www.ncbi.nlm.nih.gov/pubmed/28147339
http://dx.doi.org/10.18632/oncotarget.14891
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