Transition to resistance: An unexpected role of the EMT in cancer chemoresistance

Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.(1,2) While these findings may not settle the EMT's role in metastasis...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Wei, Qiang, Wang, Xin, Tang, Shengli, Liu, Hao, Zhang, Fugui, Mohammed, Maryam K., Huang, Jiayi, Guo, Dan, Lu, Minpeng, Liu, Feng, Liu, Jianxiang, Ma, Chao, Hu, Xue, Haydon, Rex C., He, Tong-Chuan, Luu, Hue H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421998/
https://www.ncbi.nlm.nih.gov/pubmed/28491932
http://dx.doi.org/10.1016/j.gendis.2016.01.002
Descripción
Sumario:Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.(1,2) While these findings may not settle the EMT's role in metastasis, these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance.

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