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Transition to resistance: An unexpected role of the EMT in cancer chemoresistance
Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.(1,2) While these findings may not settle the EMT's role in metastasis...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chongqing Medical University
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421998/ https://www.ncbi.nlm.nih.gov/pubmed/28491932 http://dx.doi.org/10.1016/j.gendis.2016.01.002 |
| _version_ | 1783234698043981824 |
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| author | Wang, Jing Wei, Qiang Wang, Xin Tang, Shengli Liu, Hao Zhang, Fugui Mohammed, Maryam K. Huang, Jiayi Guo, Dan Lu, Minpeng Liu, Feng Liu, Jianxiang Ma, Chao Hu, Xue Haydon, Rex C. He, Tong-Chuan Luu, Hue H. |
| author_facet | Wang, Jing Wei, Qiang Wang, Xin Tang, Shengli Liu, Hao Zhang, Fugui Mohammed, Maryam K. Huang, Jiayi Guo, Dan Lu, Minpeng Liu, Feng Liu, Jianxiang Ma, Chao Hu, Xue Haydon, Rex C. He, Tong-Chuan Luu, Hue H. |
| author_sort | Wang, Jing |
| collection | PubMed |
| description | Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.(1,2) While these findings may not settle the EMT's role in metastasis, these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. |
| format | Online Article Text |
| id | pubmed-5421998 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Chongqing Medical University |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54219982017-05-08 Transition to resistance: An unexpected role of the EMT in cancer chemoresistance Wang, Jing Wei, Qiang Wang, Xin Tang, Shengli Liu, Hao Zhang, Fugui Mohammed, Maryam K. Huang, Jiayi Guo, Dan Lu, Minpeng Liu, Feng Liu, Jianxiang Ma, Chao Hu, Xue Haydon, Rex C. He, Tong-Chuan Luu, Hue H. Genes Dis Article Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.(1,2) While these findings may not settle the EMT's role in metastasis, these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. Chongqing Medical University 2016-01-28 /pmc/articles/PMC5421998/ /pubmed/28491932 http://dx.doi.org/10.1016/j.gendis.2016.01.002 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Wang, Jing Wei, Qiang Wang, Xin Tang, Shengli Liu, Hao Zhang, Fugui Mohammed, Maryam K. Huang, Jiayi Guo, Dan Lu, Minpeng Liu, Feng Liu, Jianxiang Ma, Chao Hu, Xue Haydon, Rex C. He, Tong-Chuan Luu, Hue H. Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title | Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title_full | Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title_fullStr | Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title_full_unstemmed | Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title_short | Transition to resistance: An unexpected role of the EMT in cancer chemoresistance |
| title_sort | transition to resistance: an unexpected role of the emt in cancer chemoresistance |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421998/ https://www.ncbi.nlm.nih.gov/pubmed/28491932 http://dx.doi.org/10.1016/j.gendis.2016.01.002 |
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