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Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting

Most of the cancers are still incurable human diseases. According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiat...

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Detalles Bibliográficos
Autores principales: Eun, Kiyoung, Ham, Seok Won, Kim, Hyunggee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422023/
https://www.ncbi.nlm.nih.gov/pubmed/27998397
http://dx.doi.org/10.5483/BMBRep.2017.50.3.222
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author Eun, Kiyoung
Ham, Seok Won
Kim, Hyunggee
author_facet Eun, Kiyoung
Ham, Seok Won
Kim, Hyunggee
author_sort Eun, Kiyoung
collection PubMed
description Most of the cancers are still incurable human diseases. According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. Despite the numerous efforts to target CSCs, current anti-cancer therapies are still impeded by CSC-derived cancer malignancies; increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. One of the most forceful underlying reasons is a “cancer heterogeneity” due to “CSC plasticity” A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. Here, we introduce findings on mechanisms of CSC reprogramming and CSC plasticity, which give rise to phenotypically varied CSCs. Also, we suggest concepts to improve CSC-targeted therapy in order to overcome therapeutic resistance caused by CSC plasticity and heterogeneity.
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spelling pubmed-54220232017-05-19 Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting Eun, Kiyoung Ham, Seok Won Kim, Hyunggee BMB Rep Invited Mini Review Most of the cancers are still incurable human diseases. According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. Despite the numerous efforts to target CSCs, current anti-cancer therapies are still impeded by CSC-derived cancer malignancies; increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. One of the most forceful underlying reasons is a “cancer heterogeneity” due to “CSC plasticity” A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. Here, we introduce findings on mechanisms of CSC reprogramming and CSC plasticity, which give rise to phenotypically varied CSCs. Also, we suggest concepts to improve CSC-targeted therapy in order to overcome therapeutic resistance caused by CSC plasticity and heterogeneity. Korean Society for Biochemistry and Molecular Biology 2017-03 2017-03-31 /pmc/articles/PMC5422023/ /pubmed/27998397 http://dx.doi.org/10.5483/BMBRep.2017.50.3.222 Text en Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Eun, Kiyoung
Ham, Seok Won
Kim, Hyunggee
Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title_full Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title_fullStr Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title_full_unstemmed Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title_short Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting
title_sort cancer stem cell heterogeneity: origin and new perspectives on csc targeting
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422023/
https://www.ncbi.nlm.nih.gov/pubmed/27998397
http://dx.doi.org/10.5483/BMBRep.2017.50.3.222
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