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Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways

Non-small-cell lung cancer (NSCLC) is the third most common cancer that spreads to the bone, resulting in osteolytic lesions caused by hyperactivation of osteoclasts. Activating mutations in epidermal growth factor receptor-tyrosine kinase (EGF-TK) are frequently associated with NSCLC, and afatinib...

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Detalles Bibliográficos
Autores principales:	Ihn, Hye Jung, Kim, Ju Ang, Bae, Yong Chul, Shin, Hong-In, Baek, Moon-Chang, Park, Eui Kyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422028/ https://www.ncbi.nlm.nih.gov/pubmed/28256196 http://dx.doi.org/10.5483/BMBRep.2017.50.3.223

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