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Horizontal and vertical optic disc rotation. The Beijing Eye Study

PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50–93 years) underwent an opht...

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Autores principales: Fan, Yuan Yuan, Jonas, Jost B., Wang, Ya Xing, Chen, Chang Xi, Wei, Wen Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422037/
https://www.ncbi.nlm.nih.gov/pubmed/28481929
http://dx.doi.org/10.1371/journal.pone.0175749
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author Fan, Yuan Yuan
Jonas, Jost B.
Wang, Ya Xing
Chen, Chang Xi
Wei, Wen Bin
author_facet Fan, Yuan Yuan
Jonas, Jost B.
Wang, Ya Xing
Chen, Chang Xi
Wei, Wen Bin
author_sort Fan, Yuan Yuan
collection PubMed
description PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50–93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis. RESULTS: Optic disc rotation measurements were available for 3037 (87.6%) individuals. In multivariate analysis, larger optic disc rotation around the vertical axis (range:-4.90° to 41.0°) was associated (regression coefficient r:0.27) with high axial myopia (axial length ≥26.5 mm) (P<0.001;standardized regression coefficient beta beta:0.09), longer disc-fovea distance (P = 0.001;beta:0.09) and wider parapapillary beta/gamma zone (P<0.001;beta0.12). Larger optic disc rotation around the horizontal axis (range:-7.10° to 26.4°) was associated (r:0.32) with high axial myopia (P = 0.001;beta:0.08), larger optic disc-fovea angle (P<0.001;beta:0.13), thinner superior nasal retinal nerve fiber layer (RNFL) thickness (P<0.001;beta:-0.19) and thicker inferior nasal RNFL thickness (P<0.001;beta:0.17). CONCLUSIONS: Vertical optic disc rotation was associated with highly myopic axial elongation, increased disc-fovea distance and development or enlargement of parapapillary, Bruch´s membrane free, gamma zone, while macular Bruch´s membrane length is not affected. Horizontal optic disc rotation was associated with inferior dislocation of the fovea, in addition to a thinner superior nasal RNFL and thicker inferior nasal RNFL. The latter association may be taken into account in the interpretation of RNFL thickness profiles.
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spelling pubmed-54220372017-05-14 Horizontal and vertical optic disc rotation. The Beijing Eye Study Fan, Yuan Yuan Jonas, Jost B. Wang, Ya Xing Chen, Chang Xi Wei, Wen Bin PLoS One Research Article PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50–93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis. RESULTS: Optic disc rotation measurements were available for 3037 (87.6%) individuals. In multivariate analysis, larger optic disc rotation around the vertical axis (range:-4.90° to 41.0°) was associated (regression coefficient r:0.27) with high axial myopia (axial length ≥26.5 mm) (P<0.001;standardized regression coefficient beta beta:0.09), longer disc-fovea distance (P = 0.001;beta:0.09) and wider parapapillary beta/gamma zone (P<0.001;beta0.12). Larger optic disc rotation around the horizontal axis (range:-7.10° to 26.4°) was associated (r:0.32) with high axial myopia (P = 0.001;beta:0.08), larger optic disc-fovea angle (P<0.001;beta:0.13), thinner superior nasal retinal nerve fiber layer (RNFL) thickness (P<0.001;beta:-0.19) and thicker inferior nasal RNFL thickness (P<0.001;beta:0.17). CONCLUSIONS: Vertical optic disc rotation was associated with highly myopic axial elongation, increased disc-fovea distance and development or enlargement of parapapillary, Bruch´s membrane free, gamma zone, while macular Bruch´s membrane length is not affected. Horizontal optic disc rotation was associated with inferior dislocation of the fovea, in addition to a thinner superior nasal RNFL and thicker inferior nasal RNFL. The latter association may be taken into account in the interpretation of RNFL thickness profiles. Public Library of Science 2017-05-08 /pmc/articles/PMC5422037/ /pubmed/28481929 http://dx.doi.org/10.1371/journal.pone.0175749 Text en © 2017 Fan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fan, Yuan Yuan
Jonas, Jost B.
Wang, Ya Xing
Chen, Chang Xi
Wei, Wen Bin
Horizontal and vertical optic disc rotation. The Beijing Eye Study
title Horizontal and vertical optic disc rotation. The Beijing Eye Study
title_full Horizontal and vertical optic disc rotation. The Beijing Eye Study
title_fullStr Horizontal and vertical optic disc rotation. The Beijing Eye Study
title_full_unstemmed Horizontal and vertical optic disc rotation. The Beijing Eye Study
title_short Horizontal and vertical optic disc rotation. The Beijing Eye Study
title_sort horizontal and vertical optic disc rotation. the beijing eye study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422037/
https://www.ncbi.nlm.nih.gov/pubmed/28481929
http://dx.doi.org/10.1371/journal.pone.0175749
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