Cargando…

Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria

AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertak...

Descripción completa

Detalles Bibliográficos
Autores principales: Wungak, Yiltawe Simwal, Ishola, Olayinka O., Olugasa, Babasola O., Lazarus, David D., Ehizibolo, David O., Ularamu, Hussaini G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422250/
https://www.ncbi.nlm.nih.gov/pubmed/28507418
http://dx.doi.org/10.14202/vetworld.2017.450-456
_version_ 1783234734008041472
author Wungak, Yiltawe Simwal
Ishola, Olayinka O.
Olugasa, Babasola O.
Lazarus, David D.
Ehizibolo, David O.
Ularamu, Hussaini G.
author_facet Wungak, Yiltawe Simwal
Ishola, Olayinka O.
Olugasa, Babasola O.
Lazarus, David D.
Ehizibolo, David O.
Ularamu, Hussaini G.
author_sort Wungak, Yiltawe Simwal
collection PubMed
description AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertaken, during which a total of 155 sera that tested positive for foot-and-mouth disease (FMD) 3ABC non-structural protein antibodies were selected and screened for FMD structural protein serotypes, A, O, SAT 1, and SAT 2 using a solid-phase competitive enzyme-linked immunosorbent assay (ELISA). Epithelial tissue specimens were collected during outbreak investigations which were tested for FMD using an antigen capture ELISA for serotype A, O, SAT 1, and SAT 2. RESULTS: An overall serotype-specific prevalence of 79.35 (95% confidence interval [CI]: 72.4-85.18) was recorded for serotype O, 65.2% (95% CI: 57.41-72.3) for serotype A, 52.9% (95% CI: 45.03-60.67) for SAT 2, and 33.55% (95% CI: 26.45-41.26) for SAT 1. Evidence of exposure to multiple FMDV serotypes showed that 12.26% of the sera samples had antibodies against four serotypes circulating, 30.97% had antibodies against three serotypes circulating, 22.58% had antibodies against two serotypes, and 17% showed exposure to only one serotype. Clinical specimens (epithelial tissue) collected during outbreak investigations showed that serotype O has the highest proportion of 50% with serotype A - 25%; SAT 2 - 20.8%; and SAT 1 - 4.1%. CONCLUSION: The study detected diffuse and co-circulation of serotypes A, O, SAT 1, and SAT 2 within the study area, and hence the need for the appropriately matched multivalent vaccine is strongly advocated for FMD control in Nigeria.
format Online
Article
Text
id pubmed-5422250
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Veterinary World
record_format MEDLINE/PubMed
spelling pubmed-54222502017-05-15 Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria Wungak, Yiltawe Simwal Ishola, Olayinka O. Olugasa, Babasola O. Lazarus, David D. Ehizibolo, David O. Ularamu, Hussaini G. Vet World Research Article AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertaken, during which a total of 155 sera that tested positive for foot-and-mouth disease (FMD) 3ABC non-structural protein antibodies were selected and screened for FMD structural protein serotypes, A, O, SAT 1, and SAT 2 using a solid-phase competitive enzyme-linked immunosorbent assay (ELISA). Epithelial tissue specimens were collected during outbreak investigations which were tested for FMD using an antigen capture ELISA for serotype A, O, SAT 1, and SAT 2. RESULTS: An overall serotype-specific prevalence of 79.35 (95% confidence interval [CI]: 72.4-85.18) was recorded for serotype O, 65.2% (95% CI: 57.41-72.3) for serotype A, 52.9% (95% CI: 45.03-60.67) for SAT 2, and 33.55% (95% CI: 26.45-41.26) for SAT 1. Evidence of exposure to multiple FMDV serotypes showed that 12.26% of the sera samples had antibodies against four serotypes circulating, 30.97% had antibodies against three serotypes circulating, 22.58% had antibodies against two serotypes, and 17% showed exposure to only one serotype. Clinical specimens (epithelial tissue) collected during outbreak investigations showed that serotype O has the highest proportion of 50% with serotype A - 25%; SAT 2 - 20.8%; and SAT 1 - 4.1%. CONCLUSION: The study detected diffuse and co-circulation of serotypes A, O, SAT 1, and SAT 2 within the study area, and hence the need for the appropriately matched multivalent vaccine is strongly advocated for FMD control in Nigeria. Veterinary World 2017-04 2017-04-26 /pmc/articles/PMC5422250/ /pubmed/28507418 http://dx.doi.org/10.14202/vetworld.2017.450-456 Text en Copyright: © Wungak, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wungak, Yiltawe Simwal
Ishola, Olayinka O.
Olugasa, Babasola O.
Lazarus, David D.
Ehizibolo, David O.
Ularamu, Hussaini G.
Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title_full Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title_fullStr Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title_full_unstemmed Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title_short Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
title_sort spatial pattern of foot-and-mouth disease virus serotypes in north central nigeria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422250/
https://www.ncbi.nlm.nih.gov/pubmed/28507418
http://dx.doi.org/10.14202/vetworld.2017.450-456
work_keys_str_mv AT wungakyiltawesimwal spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria
AT isholaolayinkao spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria
AT olugasababasolao spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria
AT lazarusdavidd spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria
AT ehizibolodavido spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria
AT ularamuhussainig spatialpatternoffootandmouthdiseasevirusserotypesinnorthcentralnigeria