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Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria
AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertak...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422250/ https://www.ncbi.nlm.nih.gov/pubmed/28507418 http://dx.doi.org/10.14202/vetworld.2017.450-456 |
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author | Wungak, Yiltawe Simwal Ishola, Olayinka O. Olugasa, Babasola O. Lazarus, David D. Ehizibolo, David O. Ularamu, Hussaini G. |
author_facet | Wungak, Yiltawe Simwal Ishola, Olayinka O. Olugasa, Babasola O. Lazarus, David D. Ehizibolo, David O. Ularamu, Hussaini G. |
author_sort | Wungak, Yiltawe Simwal |
collection | PubMed |
description | AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertaken, during which a total of 155 sera that tested positive for foot-and-mouth disease (FMD) 3ABC non-structural protein antibodies were selected and screened for FMD structural protein serotypes, A, O, SAT 1, and SAT 2 using a solid-phase competitive enzyme-linked immunosorbent assay (ELISA). Epithelial tissue specimens were collected during outbreak investigations which were tested for FMD using an antigen capture ELISA for serotype A, O, SAT 1, and SAT 2. RESULTS: An overall serotype-specific prevalence of 79.35 (95% confidence interval [CI]: 72.4-85.18) was recorded for serotype O, 65.2% (95% CI: 57.41-72.3) for serotype A, 52.9% (95% CI: 45.03-60.67) for SAT 2, and 33.55% (95% CI: 26.45-41.26) for SAT 1. Evidence of exposure to multiple FMDV serotypes showed that 12.26% of the sera samples had antibodies against four serotypes circulating, 30.97% had antibodies against three serotypes circulating, 22.58% had antibodies against two serotypes, and 17% showed exposure to only one serotype. Clinical specimens (epithelial tissue) collected during outbreak investigations showed that serotype O has the highest proportion of 50% with serotype A - 25%; SAT 2 - 20.8%; and SAT 1 - 4.1%. CONCLUSION: The study detected diffuse and co-circulation of serotypes A, O, SAT 1, and SAT 2 within the study area, and hence the need for the appropriately matched multivalent vaccine is strongly advocated for FMD control in Nigeria. |
format | Online Article Text |
id | pubmed-5422250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-54222502017-05-15 Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria Wungak, Yiltawe Simwal Ishola, Olayinka O. Olugasa, Babasola O. Lazarus, David D. Ehizibolo, David O. Ularamu, Hussaini G. Vet World Research Article AIM: This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria. MATERIALS AND METHODS: A cross-sectional study was undertaken, during which a total of 155 sera that tested positive for foot-and-mouth disease (FMD) 3ABC non-structural protein antibodies were selected and screened for FMD structural protein serotypes, A, O, SAT 1, and SAT 2 using a solid-phase competitive enzyme-linked immunosorbent assay (ELISA). Epithelial tissue specimens were collected during outbreak investigations which were tested for FMD using an antigen capture ELISA for serotype A, O, SAT 1, and SAT 2. RESULTS: An overall serotype-specific prevalence of 79.35 (95% confidence interval [CI]: 72.4-85.18) was recorded for serotype O, 65.2% (95% CI: 57.41-72.3) for serotype A, 52.9% (95% CI: 45.03-60.67) for SAT 2, and 33.55% (95% CI: 26.45-41.26) for SAT 1. Evidence of exposure to multiple FMDV serotypes showed that 12.26% of the sera samples had antibodies against four serotypes circulating, 30.97% had antibodies against three serotypes circulating, 22.58% had antibodies against two serotypes, and 17% showed exposure to only one serotype. Clinical specimens (epithelial tissue) collected during outbreak investigations showed that serotype O has the highest proportion of 50% with serotype A - 25%; SAT 2 - 20.8%; and SAT 1 - 4.1%. CONCLUSION: The study detected diffuse and co-circulation of serotypes A, O, SAT 1, and SAT 2 within the study area, and hence the need for the appropriately matched multivalent vaccine is strongly advocated for FMD control in Nigeria. Veterinary World 2017-04 2017-04-26 /pmc/articles/PMC5422250/ /pubmed/28507418 http://dx.doi.org/10.14202/vetworld.2017.450-456 Text en Copyright: © Wungak, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wungak, Yiltawe Simwal Ishola, Olayinka O. Olugasa, Babasola O. Lazarus, David D. Ehizibolo, David O. Ularamu, Hussaini G. Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title | Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title_full | Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title_fullStr | Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title_full_unstemmed | Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title_short | Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria |
title_sort | spatial pattern of foot-and-mouth disease virus serotypes in north central nigeria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422250/ https://www.ncbi.nlm.nih.gov/pubmed/28507418 http://dx.doi.org/10.14202/vetworld.2017.450-456 |
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