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Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China

OBJECTIVE: This study aims to evaluate the natural history of patients with chronic lymphocytic leukemia (CLL) and a 17p deletion (17p-) and identify the predictive factors within this subgroup. METHODS: The sample of patients with CLL were analyzed by fluorescencein situ hybridization for deletions...

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Autores principales: Li, Heng, Xiong, Wenjie, Liu, Huimin, Yi, Shuhua, Yu, Zhen, Liu, Wei, Lyu, Rui, Wang, Tingyu, Zou, Dehui, Li, Zengjun, Qiu, Lugui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422418/
https://www.ncbi.nlm.nih.gov/pubmed/28536495
http://dx.doi.org/10.21147/j.issn.1000-9604.2017.02.09
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author Li, Heng
Xiong, Wenjie
Liu, Huimin
Yi, Shuhua
Yu, Zhen
Liu, Wei
Lyu, Rui
Wang, Tingyu
Zou, Dehui
Li, Zengjun
Qiu, Lugui
author_facet Li, Heng
Xiong, Wenjie
Liu, Huimin
Yi, Shuhua
Yu, Zhen
Liu, Wei
Lyu, Rui
Wang, Tingyu
Zou, Dehui
Li, Zengjun
Qiu, Lugui
author_sort Li, Heng
collection PubMed
description OBJECTIVE: This study aims to evaluate the natural history of patients with chronic lymphocytic leukemia (CLL) and a 17p deletion (17p-) and identify the predictive factors within this subgroup. METHODS: The sample of patients with CLL were analyzed by fluorescencein situ hybridization for deletions in chromosome bands 11q22, 13q14 and 17p13; trisomy of bands 12q13; and translocation involving band 14q32. The data from 456 patients with or without a 17p- were retrospectively collected and analyzed. RESULTS: The overall response rate (ORR) in patients with a 17p- was 56.9%, and patients with a high percentage of 17p- (defined as more than 25% of cells harbouring a 17p-) had a lower ORR. The median overall survival (OS) in patients with a 17p- was 78.0 months, which was significantly shorter than the OS in patients without this genetic abnormality (median 162.0 months, P<0.001). Within the subgroup with a 17p-, the progression-free survival was significantly shorter in patients at Binet stage B-C and patients with elevated lactate dehydrogenase (LDH), B symptoms, unmutatedIGHV and a high percentage of 17p-. CONCLUSIONS: These results indicated that patients with a 17p- CLL have a variable prognosis that might be predicted using simple clinical and laboratory characteristics.
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spelling pubmed-54224182017-05-23 Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China Li, Heng Xiong, Wenjie Liu, Huimin Yi, Shuhua Yu, Zhen Liu, Wei Lyu, Rui Wang, Tingyu Zou, Dehui Li, Zengjun Qiu, Lugui Chin J Cancer Res Original Article OBJECTIVE: This study aims to evaluate the natural history of patients with chronic lymphocytic leukemia (CLL) and a 17p deletion (17p-) and identify the predictive factors within this subgroup. METHODS: The sample of patients with CLL were analyzed by fluorescencein situ hybridization for deletions in chromosome bands 11q22, 13q14 and 17p13; trisomy of bands 12q13; and translocation involving band 14q32. The data from 456 patients with or without a 17p- were retrospectively collected and analyzed. RESULTS: The overall response rate (ORR) in patients with a 17p- was 56.9%, and patients with a high percentage of 17p- (defined as more than 25% of cells harbouring a 17p-) had a lower ORR. The median overall survival (OS) in patients with a 17p- was 78.0 months, which was significantly shorter than the OS in patients without this genetic abnormality (median 162.0 months, P<0.001). Within the subgroup with a 17p-, the progression-free survival was significantly shorter in patients at Binet stage B-C and patients with elevated lactate dehydrogenase (LDH), B symptoms, unmutatedIGHV and a high percentage of 17p-. CONCLUSIONS: These results indicated that patients with a 17p- CLL have a variable prognosis that might be predicted using simple clinical and laboratory characteristics. AME Publishing Company 2017-04 /pmc/articles/PMC5422418/ /pubmed/28536495 http://dx.doi.org/10.21147/j.issn.1000-9604.2017.02.09 Text en Copyright © 2017 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Article
Li, Heng
Xiong, Wenjie
Liu, Huimin
Yi, Shuhua
Yu, Zhen
Liu, Wei
Lyu, Rui
Wang, Tingyu
Zou, Dehui
Li, Zengjun
Qiu, Lugui
Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title_full Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title_fullStr Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title_full_unstemmed Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title_short Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China
title_sort serum ldh level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422418/
https://www.ncbi.nlm.nih.gov/pubmed/28536495
http://dx.doi.org/10.21147/j.issn.1000-9604.2017.02.09
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