Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes

Oncolytic virotherapy is an emerging immunotherapeutic modality for cancer treatment. Oncolytic viruses with genetic modifications can further enhance the oncolytic effects on tumor cells and stimulate antitumor immunity. The oncolytic vaccinia viruses JX-594-GFP+/hGM-CSF (JX-GFP) and TG6002 are gen...

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Detalles Bibliográficos
Autores principales: Heinrich, B, Klein, J, Delic, M, Goepfert, K, Engel, V, Geberzahn, L, Lusky, M, Erbs, P, Preville, X, Moehler, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422459/
https://www.ncbi.nlm.nih.gov/pubmed/28496337
http://dx.doi.org/10.2147/OTT.S126320

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