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Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice
The roles of D-serine in depression are raised concerned recently as an intrinsic co-agonist for the NMDA receptor. However, the mechanisms underlying its regulation are not fully elucidated. ASCT2 is a Na(+)-dependent D-serine transporter. We found that decreased D-serine and increased hippocampal...
Autores principales: | Wang, Jiesi, Zhang, Ke, Chen, Xiaojuan, Liu, Xiaoqian, Teng, Huajing, Zhao, Mei, Sun, Zhongsheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422558/ https://www.ncbi.nlm.nih.gov/pubmed/28536503 http://dx.doi.org/10.3389/fnmol.2017.00139 |
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