Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells

BACKGROUND: Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD). Up to 50% of patients with moderate-to-severe AD in European populations have FLG-null alleles compared with a general...

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Detalles Bibliográficos
Autores principales: Leitch, Claire S., Natafji, Eenass, Yu, Cunjing, Abdul-Ghaffar, Sharizan, Madarasingha, Nayani, Venables, Zoë C., Chu, Roland, Fitch, Paul M., Muinonen-Martin, Andrew J., Campbell, Linda E., McLean, W.H. Irwin, Schwarze, Jürgen, Howie, Sarah E.M., Weller, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2016
Materias:
Atopic Dermatitis and Skin Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422581/
https://www.ncbi.nlm.nih.gov/pubmed/26934939
http://dx.doi.org/10.1016/j.jaci.2015.11.040

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