Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer

Long non-coding RNAs (lncRNAs) are a group of non-coding transcripts of more than 200 nucleotides that play important biological and clinical roles in prostate cancer (PCa) tumorigenesis, progression and metastasis. They have also shown potential as a biomarker in the diagnosis and prognosis of this...

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Detalles Bibliográficos
Autores principales: Ghiam, Alireza Fotouhi, Vesprini, Danny, Liu, Stanley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422697/
https://www.ncbi.nlm.nih.gov/pubmed/28540248
http://dx.doi.org/10.21037/tau.2017.03.06
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author Ghiam, Alireza Fotouhi
Vesprini, Danny
Liu, Stanley K.
author_facet Ghiam, Alireza Fotouhi
Vesprini, Danny
Liu, Stanley K.
author_sort Ghiam, Alireza Fotouhi
collection PubMed
description Long non-coding RNAs (lncRNAs) are a group of non-coding transcripts of more than 200 nucleotides that play important biological and clinical roles in prostate cancer (PCa) tumorigenesis, progression and metastasis. They have also shown potential as a biomarker in the diagnosis and prognosis of this disease. LncRNA prostate cancer associated transcript-14 (PCAT-14) was recently identified as a novel prognostic biomarker in PCa, whose low expression was associated with poor outcomes. Here, we briefly discuss future perspectives and clinical applications of lncRNAs as biomarkers and therapeutic targets for PCa.
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spelling pubmed-54226972017-05-24 Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer Ghiam, Alireza Fotouhi Vesprini, Danny Liu, Stanley K. Transl Androl Urol Editorial Long non-coding RNAs (lncRNAs) are a group of non-coding transcripts of more than 200 nucleotides that play important biological and clinical roles in prostate cancer (PCa) tumorigenesis, progression and metastasis. They have also shown potential as a biomarker in the diagnosis and prognosis of this disease. LncRNA prostate cancer associated transcript-14 (PCAT-14) was recently identified as a novel prognostic biomarker in PCa, whose low expression was associated with poor outcomes. Here, we briefly discuss future perspectives and clinical applications of lncRNAs as biomarkers and therapeutic targets for PCa. AME Publishing Company 2017-04 /pmc/articles/PMC5422697/ /pubmed/28540248 http://dx.doi.org/10.21037/tau.2017.03.06 Text en 2017 Translational Andrology and Urology. All rights reserved.
spellingShingle Editorial
Ghiam, Alireza Fotouhi
Vesprini, Danny
Liu, Stanley K.
Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title_full Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title_fullStr Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title_full_unstemmed Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title_short Long non-coding RNAs: new frontiers for advancing personalized cancer medicine in prostate cancer
title_sort long non-coding rnas: new frontiers for advancing personalized cancer medicine in prostate cancer
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422697/
https://www.ncbi.nlm.nih.gov/pubmed/28540248
http://dx.doi.org/10.21037/tau.2017.03.06
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