Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report

Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy o...

Descripción completa

Detalles Bibliográficos
Autores principales: Damato, Angela, Larocca, Mario, Rondini, Ermanno, Menga, Massimo, Pinto, Carmine, Versari, Annibale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422735/
https://www.ncbi.nlm.nih.gov/pubmed/28512407
http://dx.doi.org/10.1159/000464440
_version_ 1783234838367567872
author Damato, Angela
Larocca, Mario
Rondini, Ermanno
Menga, Massimo
Pinto, Carmine
Versari, Annibale
author_facet Damato, Angela
Larocca, Mario
Rondini, Ermanno
Menga, Massimo
Pinto, Carmine
Versari, Annibale
author_sort Damato, Angela
collection PubMed
description Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. Here, we describe a case of reversible rhabdomyolysis in a male patient with recurrent metastatic synovial sarcoma of the hand, with marked (18)F-FDG uptake into his skeletal muscles, after 4 cycles of trabectedin, and who at the same time was taking an alternative medicine (bioflavonoids) suspected of triggering this adverse event.
format Online
Article
Text
id pubmed-5422735
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-54227352017-05-16 Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report Damato, Angela Larocca, Mario Rondini, Ermanno Menga, Massimo Pinto, Carmine Versari, Annibale Case Rep Oncol Case Report Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. Here, we describe a case of reversible rhabdomyolysis in a male patient with recurrent metastatic synovial sarcoma of the hand, with marked (18)F-FDG uptake into his skeletal muscles, after 4 cycles of trabectedin, and who at the same time was taking an alternative medicine (bioflavonoids) suspected of triggering this adverse event. S. Karger AG 2017-03-28 /pmc/articles/PMC5422735/ /pubmed/28512407 http://dx.doi.org/10.1159/000464440 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Damato, Angela
Larocca, Mario
Rondini, Ermanno
Menga, Massimo
Pinto, Carmine
Versari, Annibale
Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title_full Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title_fullStr Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title_full_unstemmed Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title_short Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report
title_sort severe rhabdomyolysis during treatment with trabectedin in combination with a herbal drug in a patient with metastatic synovial sarcoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422735/
https://www.ncbi.nlm.nih.gov/pubmed/28512407
http://dx.doi.org/10.1159/000464440
work_keys_str_mv AT damatoangela severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport
AT laroccamario severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport
AT rondiniermanno severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport
AT mengamassimo severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport
AT pintocarmine severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport
AT versariannibale severerhabdomyolysisduringtreatmentwithtrabectedinincombinationwithaherbaldruginapatientwithmetastaticsynovialsarcomaacasereport

Ejemplares similares