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Molecular dynamics simulation of the opposite-base preference and interactions in the active site of formamidopyrimidine-DNA glycosylase

BACKGROUND: Formamidopyrimidine-DNA glycosylase (Fpg) removes abundant pre-mutagenic 8-oxoguanine (oxoG) bases from DNA through nucleophilic attack of its N-terminal proline at C1′ of the damaged nucleotide. Since oxoG efficiently pairs with both C and A, Fpg must excise oxoG from pairs with C but n...

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Detalles Bibliográficos
Autores principales:	Popov, Alexander V., Endutkin, Anton V., Vorobjev, Yuri N., Zharkov, Dmitry O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422863/ https://www.ncbi.nlm.nih.gov/pubmed/28482831 http://dx.doi.org/10.1186/s12900-017-0075-y

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