Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report

BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of c...

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Detalles Bibliográficos
Autores principales: Cazzolla, Angela Pia, Troiano, Giuseppe, Zhurakivska, Khrystyna, Maiorano, Eugenio, Favia, Gianfranco, Lacaita, Maria Grazia, Marzo, Giuseppe, Dicuonzo, Franca, Andresciani, Stefano, Muzio, Lorenzo Lo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422897/
https://www.ncbi.nlm.nih.gov/pubmed/28482919
http://dx.doi.org/10.1186/s13256-017-1286-3
Descripción
Sumario:BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION: We report a case of Langerhans cell histiocytosis, which presented as an osteolytic lesion of the left pre-maxillae enclosing the deciduous incisor and canine in a 7-month-old white Italian boy. He was treated with chemotherapy. He achieved complete remission after 7 months and after 24 months no signs of recurrence were observed. CONCLUSIONS: As a result of this treatment, anesthetic sequelae and loss of teeth were avoided; in addition, we prevented a loss of the vertical dimension of occlusion.

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