Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report

BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of c...

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Autores principales: Cazzolla, Angela Pia, Troiano, Giuseppe, Zhurakivska, Khrystyna, Maiorano, Eugenio, Favia, Gianfranco, Lacaita, Maria Grazia, Marzo, Giuseppe, Dicuonzo, Franca, Andresciani, Stefano, Muzio, Lorenzo Lo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422897/
https://www.ncbi.nlm.nih.gov/pubmed/28482919
http://dx.doi.org/10.1186/s13256-017-1286-3
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author Cazzolla, Angela Pia
Troiano, Giuseppe
Zhurakivska, Khrystyna
Maiorano, Eugenio
Favia, Gianfranco
Lacaita, Maria Grazia
Marzo, Giuseppe
Dicuonzo, Franca
Andresciani, Stefano
Muzio, Lorenzo Lo
author_facet Cazzolla, Angela Pia
Troiano, Giuseppe
Zhurakivska, Khrystyna
Maiorano, Eugenio
Favia, Gianfranco
Lacaita, Maria Grazia
Marzo, Giuseppe
Dicuonzo, Franca
Andresciani, Stefano
Muzio, Lorenzo Lo
author_sort Cazzolla, Angela Pia
collection PubMed
description BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION: We report a case of Langerhans cell histiocytosis, which presented as an osteolytic lesion of the left pre-maxillae enclosing the deciduous incisor and canine in a 7-month-old white Italian boy. He was treated with chemotherapy. He achieved complete remission after 7 months and after 24 months no signs of recurrence were observed. CONCLUSIONS: As a result of this treatment, anesthetic sequelae and loss of teeth were avoided; in addition, we prevented a loss of the vertical dimension of occlusion.
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spelling pubmed-54228972017-05-12 Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report Cazzolla, Angela Pia Troiano, Giuseppe Zhurakivska, Khrystyna Maiorano, Eugenio Favia, Gianfranco Lacaita, Maria Grazia Marzo, Giuseppe Dicuonzo, Franca Andresciani, Stefano Muzio, Lorenzo Lo J Med Case Rep Case Report BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION: We report a case of Langerhans cell histiocytosis, which presented as an osteolytic lesion of the left pre-maxillae enclosing the deciduous incisor and canine in a 7-month-old white Italian boy. He was treated with chemotherapy. He achieved complete remission after 7 months and after 24 months no signs of recurrence were observed. CONCLUSIONS: As a result of this treatment, anesthetic sequelae and loss of teeth were avoided; in addition, we prevented a loss of the vertical dimension of occlusion. BioMed Central 2017-05-09 /pmc/articles/PMC5422897/ /pubmed/28482919 http://dx.doi.org/10.1186/s13256-017-1286-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Cazzolla, Angela Pia
Troiano, Giuseppe
Zhurakivska, Khrystyna
Maiorano, Eugenio
Favia, Gianfranco
Lacaita, Maria Grazia
Marzo, Giuseppe
Dicuonzo, Franca
Andresciani, Stefano
Muzio, Lorenzo Lo
Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title_full Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title_fullStr Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title_full_unstemmed Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title_short Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
title_sort langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422897/
https://www.ncbi.nlm.nih.gov/pubmed/28482919
http://dx.doi.org/10.1186/s13256-017-1286-3
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