KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

BACKGROUND: Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na(+)/Ca(2+) exchangers (NCX1-3) are implicated in Ca(2+) brain homeostasis; normally, they extrude Ca(...

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Detalles Bibliográficos
Autores principales: Hernandez-Ojeda, Mariana, Ureña-Guerrero, Monica E., Gutierrez-Barajas, Paola E., Cardenas-Castillo, Jazmin A., Camins, Antoni, Beas-Zarate, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423021/
https://www.ncbi.nlm.nih.gov/pubmed/28486943
http://dx.doi.org/10.1186/s12929-017-0335-y

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